Betaine Hydrochloride - Pariet (Rabeprazole) Interaction

Herbal: Betaine Hydrochloride
Also Known As: Trimethylglycine hydrochloride

Drug: Rabeprazole
Brand names: Pariet

Medical Content Editor
Last updated Jul 22, 2023

Interaction Details

Rabeprazole is classified as belonging to the following category: Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Interaction Rating

Minor

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014
  • Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7.

Betaine Hydrochloride Overview

Betaine Hydrochloride Betaine hydrochloride (HCL) is a supplement that is sometimes used to increase the amount of hydrochloric acid in the stomach. Hydrochloric acid is an important component of stomach acid that helps to break down food and kill harmful bacteria. As a dietary supplement, it is used to help with digestion problems such as bloating, gas, and indigestion. It is also used to help people with conditions such as low stomach acid, heartburn, and acid reflux.
See More Information Regarding Betaine Hydrochloride

Rabeprazole Overview

  • Rabeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube that connects the throat and stomach) in adults and children 12 year of age and older. Rabeprazole is used to treat damage from GERD, allow the esophagus to heal, and prevent further damage to the esophagus in adults. Rabeprazole is also used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults. Rabeprazole is used to treat ulcers (sores in the lining of the stomach or intestine) and is used in combination with other medications to eliminate H. pylori (a bacteria that causes ulcers) in adults. Rabeprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.

See More Information Regarding Rabeprazole

Betaine Hydrochloride - More Interactions

Betaine Hydrochloride interacts with 36 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

Visit Our Drug-Herbal Interaction Checker

Drug-Herbal Interaction Checker

Check your medications for potential interactions with herbal supplements

Popular Interaction Pages

Pomegranate - Trichlormethiazide
Calamint - Theophylline
Bitter Orange - Dalfampridine
Yellow Loosestrife - Mavacamten
Great Plantain - Tenapanor Hydrochloride
Camphor - Fentanyl Citrate
Medium Chain Triglycerides (mcts) - Irinotecan Hydrochloride
Tolu Balsam - Opium Tincture
Grains Of Paradise - Nitroprusside
Cnidium - Estradiol, Progesterone
Deer Velvet - Valganciclovir
Histidine - Galantamine
Sitostanol - Nandrolone (prescription Drug)
Berberine - Amiloride, Hydrochlorothiazide
Oregon Fir Balsam - Dapsone
Borage - Siponimod
Pipsissewa - Colesevelam
Date Palm - Guaifenesin, Pseudoephedrine
Anise - Albendazole
Qi Gong - Tezacaftor, Ivacaftor

Return to the main herbal interaction checker page

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

Ask A Pharmacist