Black Alder - Doxorubicin Interaction
Herbal: Black Alder
Also Known As: Alnus glutinosa, Aliso Negro, Aulne Glutineux, Aulne Rouge, Aune, Aunette, Betula Alnus, Common Alder, English Alder, European Alder, European Black Alder, Owler
Drug: Doxorubicin
Brand names:
Doxil, Adriamycin, Rubex, Caelyx, Myocet
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Doxorubicin is classified as belonging to the following category: Doxorubicin (Adriamycin, Others)
Laboratory research shows that black alder bark extracts can antagonize the chemotherapeutic effects of doxorubicin. This interaction has not been evaluated in humans. Until more is known, use this combination with caution.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Dinic J, Novakovic M, Podolski-Renic A, et al. Antioxidative activity of diarylheptanoids from the bark of black alder (Alnus glutinosa) and their interaction with anticancer drugs. Planta Med 2014;80(13):1088-96. doi: 10.1055/s-0034-1382993. Epub 2014 Au
Black Alder Overview
Black alder, scientifically referred to as Alnus glutinosa, is a tree that has been employed in traditional practices for its potential health benefits. Compounds found in black alder have led to its investigation for anti-inflammatory and antimicrobial properties. Nevertheless, its usage requires caution due to potential toxicity, emphasizing the need for accurate identification and informed application.
Doxorubicin Overview
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Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells), including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML, ANLL). Doxorubicin is also used alone and in combination with other medications to treat certain types of thyroid cancer and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). It is also used to treat neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children) and Wilms' tumor (a type of kidney cancer that occurs in children). Doxorubicin is in a class of medications called anthracyclines. It works by slowing or stopping the growth of cancer cells in your body.
Black Alder - More Interactions
Black Alder interacts with 2 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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