Calamus - Xerava (Eravacycline) Interaction
Herbal: Calamus
Also Known As: Acorus calamus, Acore Calame, Acore Odorant, Acore Olorant, Acore Roseau, Acorus Roseau, Aruna, Bach, Bajai, Baje, Belle-Angélique, Bhutanashini, Cálamo, Calamo Aromatic, Calamus Root, Cinnamon Sedge, Flag Root, Flagroot, Gladdon, Golomi, Grass-Leaf Sweetflag, Grass Myrtle, Ka
Drug: Eravacycline
Brand names:
Xerava
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 16, 2024
Interaction Details
Eravacycline is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
In vitro research shows that calamus extract inhibits CYP3A4 enzyme.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.
Calamus Overview
Eravacycline Overview
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Eravacycline injection used to treat infections of the abdomen (stomach area). Eravacycline injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infection.
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Antibiotics such as eravacycline injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Calamus - More Interactions
Calamus interacts with 1091 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.