Interaction Details

Macitentan is classified as belonging to the following category: Antihypertensive Drugs

Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.
Catechu might lower blood pressure.

Interaction Rating


Likelihood of Occurrence


Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists


  • Sham JS, Chiu KW, Pang PK. Hypotensive action of Acacia catechu. Planta Med 1984;50:177-80.

Catechu Overview

Catechu Catechu, also known as catechu gum or catechu extract, is a natural substance that is extracted from the Acacia catechu tree, which is native to parts of Asia. It is a brown, sticky substance that is used in traditional medicine and as a natural dye. Catechu has a number of potential health benefits and has been used in traditional medicine for centuries. It is believed to have astringent, anti-inflammatory, and antioxidant properties, and it is often used to treat a range of health conditions, including gastrointestinal disorders, mouth sores, and skin wounds.
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Macitentan Overview

  • Macitentan is used to manage the symptoms of pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Macitentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.

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Catechu - More Interactions

Catechu interacts with 459 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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