Cinchona - Rubraca (Rucaparib Camsylate) Interaction
Herbal: Cinchona
Also Known As: Cinchona calisaya, Arbol de la Quina, Bois aux Fièvres, Calisaya Bark, Cascarilla, China Bark, Chinarinde, Chinarindenbaum, Chininbaum, Cinchonine, Écorce du Pérou, Écorce de Quina, Écorce de Quinquina Rouge, Fever Tree, Fieberrinde, Fieberrindenbaum, Jesuit's Bark
Drug: Rucaparib Camsylate
Brand names:
Rubraca
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Rucaparib Camsylate is classified as belonging to the following category: Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme. Cinchona contains quinidine, which has been shown to inhibit CYP2D6-mediated metabolism in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Bramer SL, Suri A. Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:41-51.
Cinchona Overview
Cinchona is a genus of flowering plants belonging to the Rubiaceae family. It contains around 25 different species and is native to the Andes mountains of South America. One of the most well-known species is Cinchona calisaya. The bark of cinchona is a source of quinine, an alkaloid that has been used for centuries to treat malaria. Cinchona bark is also used in traditional medicine for a variety of other ailments, including muscle cramps, restless legs, fever, arthritis, and digestive disorders. As Cinchona contains quinine, it is sometimes used as a flavoring on tonic water and alcoholic drinks. Cinchona bark has been shown to contain, on average, 5% to 15% quinoline alkaloids.
Rucaparib Camsylate Overview
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Rucaparib is used to help maintain the response to other treatments for certain types of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and primary peritoneal (layer of tissue that lines the abdomen) cancer that has returned in adults who have completely responded or partially responded to other chemotherapy treatment(s). It is also used to treat certain types of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer in people with a specific gene who have received treatment with at least two other chemotherapy treatments. Rucaparib is also used to treat certain types of prostate cancer that has spread to other areas in the body in people with a specific gene who have received other treatments. Rucaparib is in a class of medications called poly (ADP-ribose) polymerase (PARP) inhibitors. It works by killing cancer cells.
Cinchona - More Interactions
Cinchona interacts with 481 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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