Diindolylmethane - Leukine (Sargramostim) Interaction
Herbal: Diindolylmethane
Also Known As: DIM
Drug: Sargramostim
Brand names:
Leukine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Sargramostim and Diindolylmethane. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
DIM does have some theoretical drug interactions to be aware of, but they are generally believed to be only mild to moderate in nature.
Potential drug interactions with DIM include drugs in the following classes:
- Drugs that are metabolized by the liver enzyme CYP1A2: DIM may induce this enzyme, increasing the metabolism of certain drugs.
- Diuretics: DIM may reduce sodium levels, and could have additive effects with diuretics that increase sodium loss.
- Estrogen: DIM may have both estrogenic and anti-estrogen effects.
These are all detailed in individual interaction pages.
There is no known interaction between DIM and the drug in question, however.
Nevertheless, always be sure to tell your doctor about all the medications you are taking, supplements included.
- Dr. Brian Staiger, PharmDDiindolylmethane Overview
Diindolylmethane (DIM) is a compound found in cruciferous vegetables such as broccoli, cabbage, and kale. It is formed during the digestion of indole-3-carbinol, another compound found in these vegetables. DIM has been studied for its potential health benefits, including improved hormone balance and reduced risk of certain cancers. DIM (Diindolylmethane) supplements are often marketed as a natural way to support hormone balance, specifically estrogen imbalances, and as a 'detoxifying agent'. Supplements with DIM are often paired with Bioperine to improve absorption.
Sargramostim Overview
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Sargramostin is used to decrease the chance of infection in people who have acute myelogenous leukemia (AML; a type of cancer of the white blood cells) and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection). Sargramostin is also used in people who are undergoing blood stem cell transplants, in people who are undergoing bone marrow transplants, and to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the body and then returned to the body following chemotherapy). Sargramostim is also used in people who have not responded after receiving a blood marrow transplant. Sargramostin is in a class of medications called colony-stimulating factors. It works by helping the body make more neutrophils and certain other blood cells.
Diindolylmethane - More Interactions
Diindolylmethane interacts with 267 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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