Interaction Details

Chlorzoxazone is classified as belonging to the following category: Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Interaction Rating


Likelihood of Occurrence


Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.


  • Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3.

Glucomannan Overview

Glucomannan Glucomannan is a type of soluble fiber that comes from the konjac root, which is native to Asia. It is often used as a dietary supplement to promote weight loss and improve digestive health. When glucomannan is mixed with a liquid, it forms a gel-like substance that can help to reduce appetite by promoting a feeling of fullness. It can also help to regulate bowel movements and relieve constipation. Some studies have suggested that glucomannan may be effective for weight loss and it is a common ingredient in weight loss products, such as Lipozene.
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Chlorzoxazone Overview

  • Chlorzoxazone is used to relieve pain and stiffness caused by muscle strains and sprains. It is used in combination with physical therapy, analgesics (such as aspirin or acetaminophen), and rest.

See More Information Regarding Chlorzoxazone

Glucomannan - More Interactions

Glucomannan interacts with 1987 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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