Gum Arabic - Augmentin (Amoxicillin, Clavulanate Potassium) Interaction
Herbal: Gum Arabic
Also Known As: Acacia, Acacia Gum, Arabic Gum, Arbre à Gomme Arabique, Bum Senegal, Bomme Arabique, Bomme de Senegal, Bummae Momosae, Goma Arábiga, Gomme Acacia, Gomme Arabique, Gomme d'Acacia, Gomme de Senegal, Gomme Sénégal, Gommier Blanc, Gum Acacia, Gum Senegal, Gummae Mimosae, India
Drug: Amoxicillin, Clavulanate Potassium
Brand names:
Augmentin, Augmentin XR, Clavulin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin-Duo 400/57
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 16, 2024
Interaction Details
Amoxicillin, Clavulanate Potassium is classified as belonging to the following category: Oral Drugs
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8.
- Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20.
Interaction Details
Amoxicillin, Clavulanate Potassium is classified as belonging to the following category: Amoxicillin (Amoxil, Trimox)
Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8.
Gum Arabic Overview
Gum Arabic - More Interactions
Gum Arabic interacts with 1987 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.