Gymnema - Prexige (Lumiracoxib) Interaction
Also Known As: Gymnema sylvestre, Gimnema, Gur-Mar, Gurmar, Gurmari, Gurmarbooti, Gurmur, Gymnéma, Gymnéma Sylvestre, Madhunashini, Merasingi, Meshasring, Meshashringi, Miracle Plant, Periploca of the Woods, Shardunika, Vishani
Brand names: Prexige
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated Jul 22, 2023
Lumiracoxib is classified as belonging to the following category: Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.
Likelihood of OccurrencePossible
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
- Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151.
- Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10.
Gymnema - More Interactions
Gymnema interacts with 806 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
|Major||The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.|
|Moderate||Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.|
|Minor||Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.|
|Unknown||No interactions have been reported or no interaction data is currently available.|
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.