Cade Interactions Overview

Additional Details

Is Cade Safe? Are There Any Warnings?

• Cade oil, when used topically in concentrations of 1% to 5%, is likely safe for short-term use in relieving minor skin conditions.
• Caution is needed when using crude (unrectified) cade oil orally or topically, as it contains potentially carcinogenic compounds and has been associated with serious adverse effects.
• Cade should be avoided during pregnancy and lactation due to insufficient safety information.
• Oral use of cade oil has caused irritation of mucous membranes and has been linked to respiratory distress, delirium, acute renal failure, and blood dyscrasias.

How Is Cade Thought To Work? What Is the Mechanism of Action?

• Cade contains various compounds, such as catechins, flavonols, alpha-pinene, beta-phellandrene, and phenols like p-cresol and guaiacol, contributing to its potential effects.
• Antidiabetic effects: Alcoholic extracts of cade leaves and berries have shown hypoglycemic activity, mainly attributed to shikimic acid in the berries.
• Antihypertensive effects: Alcoholic extracts of cade leaves and stems can lower blood pressure without involving noradrenaline.
• Anti-inflammatory effects: Cade leaf and stem extracts have demonstrated anti-inflammatory activity in animal studies.
• Antimicrobial effects: Cade extracts inhibit the growth of various bacteria, including Staphylococcus and Pseudomonas species, and some also have activity against Candida albicans.
• Antioxidant effects: Cade extracts exhibit antioxidant properties, reducing reactive oxygen species and preventing lipid peroxidation.

Pharmacokinetics

Insufficient reliable information is available about the pharmacokinetics of cade.

Interaction Overview

No known interactions with drugs, supplements, conditions, or lab tests have been reported for cade.

Common Side Effects To Watch For

Topical application of rectified cade oil (1% to 5%) is generally well-tolerated. However, oral use of rectified or crude cade oil and topical use of crude cade oil have been associated with severe adverse effects, especially in infants and children. Symptoms include respiratory distress, convulsions, acute renal failure, hypotonia, and delirium.

Are Supplements Standardized?

There is insufficient reliable information available about the standardization of cade supplements.

What Is Cade Typically Used For [as a dietary supplement]?

• Orally, for diarrhea, peptic ulcer disease (PUD), abdominal pain, diabetes, hypertension, bronchitis, pneumonia, common cold, fever, hypotonia, kidney stones, cancer, psychiatric disorders, and promoting sleep in children.
• Orally, for gastrointestinal disorders, common cold, cough, kidney stones, hemorrhoids, and diabetes.
• Topically, for itching, psoriasis, eczema, seborrhea, scabies, head lice, leprosy, hair loss, dandruff, toothache, cancers, snake bites, wound dressing, and analgesic and antipruritic preparations for anorectal use.
• By inhalation, in incense and aromatherapy products.
• In manufacturing, rectified cade oil is used as a fragrance component in soaps, detergents, creams, lotions, shampoos, and perfumes.

Drugs that interact with Cade