Creatine Interactions Overview
Check For Interactions With Creatine
Creatine
- 2-[carbamimidoyl(methyl)amino]acetic acid
Creatine is an organic amine that occurs naturally in the body and is also found in certain foods, such as meat and fish. It is stored mostly in the skeletal muscles, where it is used to generate energy during physical activity. Creatine is a popular over-the-counter dietary supplement, and some evidence suggests it is effective at improving exercise performance, particularly during high-intensity activities such as weightlifting and sprinting. However, the degree to which creatine supplements may improve exercise performance can vary depending on the individual and the type of physical activity being performed
Creatine is generally well-tolerated but may cause some minor side effects, such as cramping and water retention in some individuals. Long-term use has been rarely linked to kidney problems, but its use is generally regarded as safe.
There are several different forms of creatine available, with the most common form being monohydrate salt. Other salt forms, including di-creatine citrate and 'pH buffered' creatine, are also available.
Additional Details
Is Creatine Safe? Are There Any Warnings?
Creatine is generally considered safe when used orally and appropriately, both short-term and long-term. It's important to follow recommended dosages and consult a healthcare professional, especially if you have underlying health conditions. Pregnant and lactating individuals should avoid using creatine due to insufficient reliable information.
How Does Creatine Work? What Is the Mechanism of Action?
Creatine is a naturally occurring compound found in the body, primarily in skeletal muscle. It plays a crucial role in energy metabolism by helping to produce adenosine triphosphate (ATP), the body's main energy currency. Creatine is synthesized in the liver and kidneys from amino acids, and it's also obtained from dietary sources like red meat and seafood.
When muscles contract during activities like exercise, ATP is rapidly consumed. Creatine helps replenish ATP levels by donating its phosphate group to ADP (adenosine diphosphate), converting it back into ATP. This process enhances the muscle's ability to perform short bursts of high-intensity activity.
In addition to energy support, creatine has been explored for its potential benefits in various areas, including improving athletic performance, reducing oxidative stress, supporting brain health, and more. It may also influence insulin sensitivity and glucose uptake in muscles, contributing to potential antidiabetic effects.
Pharmacokinetics
Creatine is efficiently absorbed from the intestines, and its absorption can be enhanced by consuming it alongside carbohydrates. The majority of creatine (about 95%) is stored in skeletal muscles, with smaller amounts found in the brain, heart, and other tissues. It's metabolized in the body and excreted primarily through the kidneys.
Common Side Effects To Watch For
Orally, creatine is generally well-tolerated. Some common side effects include dehydration, diarrhea, gastrointestinal upset, muscle cramps, and water retention. Rarely, there have been case reports of more serious adverse effects, such as renal insufficiency, rhabdomyolysis, and venous thrombosis.
Are Supplements Standardized?
Oral creatine supplements are available in various formulations, with the most common being creatine monohydrate. Other forms like di-creatine citrate and creatine nitrate are also available. However, the evidence for the superiority of these alternative forms is limited. The content and purity of creatine supplements can vary among brands, so it's essential to choose products from reputable manufacturers.
What Is Creatine Typically Used For?
Creatine is often used by athletes and fitness enthusiasts to enhance short-term, high-intensity performance during activities like weightlifting, sprinting, and jumping. It's also been explored for potential benefits in conditions such as cerebral creatine deficiency syndromes, muscle strength improvement, and certain neurological disorders. However, its effectiveness varies across these uses, and more research is needed to establish its benefits conclusively.
Drugs that interact with Creatine
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLCs