Daffodil Interactions Overview

Additional Details

Is Daffodil Safe? Are There Any Warnings?

Daffodil is considered unsafe to consume or use topically. All parts of the plant are poisonous, and ingesting any part can cause vomiting and diarrhea. Higher doses can lead to poisoning. Topical use of daffodil can cause severe dermatitis. It is strongly advised to avoid using daffodil during pregnancy and lactation due to potential risks.

How Does Daffodil Work? What is the Mechanism of Action?

Daffodil contains various alkaloids such as galanthamine, lycorine, and narciclasine, as well as chelidonic acid. Galanthamine, found in daffodil, acts as a cholinesterase inhibitor, which has been explored for the treatment of Alzheimer's disease. The plant also possesses cytotoxic effects, especially the alkaloids lycorine and narciclasine. On the dermatological front, the mucus and sap of daffodil bulbs and plants contain calcium oxalate crystals, which can irritate and damage the skin.

Pharmacokinetics

Unfortunately, there is limited information available regarding the pharmacokinetics of daffodil. More research is needed to fully understand how the body processes and metabolizes this plant.

Interaction Overview (See Bottom of Page for Full List)

Daffodil does not have any known interactions with drugs, supplements, conditions, or lab tests. However, it is theorized that daffodil might decrease the absorption of nutrients like calcium, iron, and zinc due to the presence of oxalate.

Common Side Effects to Watch For

Due to its toxic nature, daffodil can cause serious adverse effects when consumed orally. These include irritation and swelling of the mouth, tongue, and throat, as well as sudden onset of vomiting, diarrhea, and abdominal pain. In large doses, blurred vision, coma, convulsions, dizziness, headache, hypotension, excessive salivation, sweating, and tremors may occur. Topical use can result in severe dermatitis.

Are Supplements Standardized?

Information about the standardization of daffodil supplements is currently insufficient. There is a lack of reliable data on the quality control and standardization processes for these products.

What Is Daffodil Typically Used For [as a dietary supplement]?

• Traditionally used as an emetic (induces vomiting)
• Treatment for asthma, joint pain, respiratory tract infections, and wound healing (insufficient evidence for their effectiveness)

Daffodil has been of interest for its potential therapeutic effects on asthma, joint pain, respiratory tract infections, and wound healing. However, there is a lack of reliable evidence supporting its efficacy for these purposes. Further research is necessary to determine the true benefits of daffodil supplementation.

Drugs that interact with Daffodil