Elecampane Interactions Overview

Additional Details

Is Elecampane Safe? Are There Any Warnings?

Safety: Elecampane is generally considered safe when used orally in appropriate medicinal amounts. However, large oral doses can cause gastrointestinal upset and symptoms of paralysis. It is advised to avoid using elecampane during pregnancy and lactation.

Adverse Effects: The most common adverse effect is allergic contact dermatitis when used topically. In rare cases, high oral doses can lead to diarrhea, vomiting, spasms, and symptoms of paralysis.

How Is Elecampane Thought To Work? What Is the Mechanism of Action?

Mechanism of Action: The active parts of elecampane are its rhizome and root. It contains sesquiterpene alkaloids, such as alantolactone and isoalantolactone, as well as phenolic compounds like chlorogenic acid, ferulic acid, caffeic acid, and rosmarinic acid.

Anti-inflammatory effects: Elecampane shows promise in reducing inflammation in conditions like acne, acute lung injury, rheumatoid arthritis, psoriasis, and atopic dermatitis. It inhibits the production of inflammatory molecules and reduces markers of inflammation in laboratory studies.

Antimicrobial activity: The sesquiterpene alkaloids in elecampane exhibit antibacterial, antifungal, and anthelmintic (anti-parasitic) properties.

Antioxidant effects: Elecampane demonstrates antioxidant activity, which helps protect cells from damage caused by free radicals.

Antispasmodic activity: Elecampane's volatile oil has relaxant effects on smooth muscles, making it potentially useful for relieving spasms in the respiratory and digestive systems.

Dermatologic effects: Elecampane inhibits sebum production, suggesting potential benefits for managing conditions related to excess oil production in the skin.

Pharmacokinetics

There is currently insufficient reliable information available about the pharmacokinetics of elecampane.

Interaction Overview

Interactions with Drugs: Elecampane may cause additive sedative effects when taken with central nervous system depressants.

Interactions with Supplements: Elecampane may have sedative effects when used with herbs and supplements that possess similar properties.

Interactions with Conditions: No known interactions.

Interactions with Lab Tests: No known interactions.

Common Side Effects To Watch For

While there are no specific side effects reported for elecampane, it's important to be aware of any allergic reactions or unusual symptoms. If any concerns arise, seek medical attention.

Are Supplements Standardized?

There is currently insufficient reliable information available regarding the standardization of elecampane supplements.

Drugs that interact with Elecampane