Irvingia Gabonensis Interactions Overview

Additional Details

Is African Mango Safe? Are There Any Warnings?

African Mango, derived from the Irvingia gabonensis tree in Central and West Africa, is generally considered safe when used orally and appropriately in the short term. However, caution is advised during pregnancy and lactation due to insufficient reliable information.

Adverse effects are generally mild, including flatulence, mild nausea, headache, and insomnia. Serious adverse effects are rare, with one reported case of hepatitis associated with African Mango use.

How Is African Mango Thought To Work? What is the Mechanism of Action?

The seeds of Irvingia gabonensis are the primary medicinal part, containing various components such as saccharides, carbohydrates, proteins, fats, vitamins, minerals, and more. African Mango is believed to exert anti-obesity effects by inhibiting adipogenesis, modulating hormones, and demonstrating antioxidant and hypoglycemic properties.

Its fiber content may contribute to lowering cholesterol by binding bile acids in the gut, preventing reabsorption and promoting their conversion to bile acids. The high-soluble fiber also acts as a laxative, aiding gastrointestinal health.

Pharmacokinetics

Absorption of Irvingia gabonensis seeds is estimated to be between 94% and 98%. Specific seed components show varying digestibility, with protein digestibility ranging from 0.5% to 0.8% for dehulled and hulled seeds, respectively.

Interaction Overview

With Drugs: Moderate interactions may occur with antidiabetes drugs and testosterone supplements. Monitoring and cautious use are recommended.

With Supplements: Potential interactions with other hypoglycemic herbs and supplements. Close monitoring of blood glucose levels is advised.

With Conditions: Caution is advised for individuals with diabetes and those undergoing surgery.

Common Side Effects to Watch For

General side effects include flatulence, mild nausea, headache, and insomnia. Gastrointestinal and hepatic effects are reported but are generally mild. Vigilance is recommended for any unusual symptoms.

Are Supplements Standardized?

Insufficient information is available about the standardization of African Mango supplements. The variability in products should be considered when choosing a supplement.

What Is African Mango Typically Used For?

African Mango is used for obesity, weight loss, hyperlipidemia, diabetes, and pain. The seeds and fruit are also utilized for food, with the oil extracted from the seeds used in various products such as margarine, cooking oil, soap, and perfume.

Studies suggest potential effectiveness in diabetes, hypercholesterolemia, metabolic syndrome, and obesity, but more research is needed for conclusive evidence.

Drugs that interact with Irvingia Gabonensis