Wasabi Interactions Overview

Check For Interactions With Wasabi

Wasabi

Also known as
  • Eutrema japonicum
  • Cochlearia wasabi
  • Eutrema wasabi. Cardamine pseudowasabi
  • Wasabia japonica var. koreana
Wasabi Wasabi, derived from the Japanese horseradish plant, is commonly known for its pungent flavor in sushi. However, it is also gaining attention as a potential dietary supplement. Rich in compounds like isothiocyanates, wasabi exhibits anti-inflammatory and antimicrobial properties that may support immune function. Additionally, some studies suggest that its bioactive components could have antioxidant effects, contributing to cellular health.
There are 118 drugs known to interact with Wasabi

Additional Details

Is Wasabi Safe? Are There Any Warnings?

Wasabi is generally considered safe when consumed in food amounts. However, there is insufficient information regarding its safety when used for medicinal purposes. It's advised to avoid using wasabi during pregnancy and lactation due to a lack of reliable data on its safety in these situations.

How Does Wasabi Work? What is the Mechanism of Action?

Wasabi's active components, found in its roots, stems, and leaves, include allyl isothiocyanate and other compounds. Allyl isothiocyanate, predominant in the roots, contributes to the pungent flavor. Research suggests various potential mechanisms of action:

  • Antibacterial Effects: Wasabi extracts demonstrate antibacterial effects against Helicobacter pylori strains.
  • Anticancer Effects: Certain constituents inhibit the growth of cancer cells, while others may have promoting effects on specific cancers.
  • Antidiabetic Effects: Animal studies show that oral intake of wasabi leaf may prevent adverse metabolic changes associated with a high-fat diet.
  • Anti-inflammatory Effects: Wasabi constituents exhibit anti-inflammatory activity.
  • Antiplatelet Effects: Some compounds in wasabi inhibit platelet aggregation, potentially impacting blood clotting.
  • Bone Metabolism Effects: Wasabi extracts may have an anabolic effect on bone metabolism.
  • Cardiovascular Effects: Wasabi consumption has shown potential in attenuating the development of hypertension in animal studies.
  • Hepatic and Hypocholesterolemic Effects: Wasabi may have positive effects on the liver, reducing liver-related issues and improving cholesterol levels.
  • Gastrointestinal Effects: Wasabi extracts demonstrate activity in models of irritable bowel syndrome and colitis.
  • Muscle Effects: Certain compounds in wasabi may impact muscle strength and damage during exercise.
  • Nervous System Effects: Allyl isothiocyanate, the pungent component, activates a pain pathway in sensory neurons.

Pharmacokinetics

Unfortunately, there is insufficient reliable information available about the pharmacokinetics of wasabi.

Interaction Overview

With Drugs: Wasabi may interact with anticoagulant/antiplatelet drugs, increasing the risk of bleeding. Caution is advised in such combinations.

With Supplements: Theoretically, wasabi may increase bleeding risk when used with anticoagulant/antiplatelet herbs and supplements.

With Conditions: Individuals with bleeding disorders or those undergoing perioperative care should exercise caution with wasabi.

Common Side Effects To Watch For

No general adverse effects have been reported with wasabi use. However, a comprehensive safety evaluation is yet to be conducted.

Are Supplements Standardized?

Information on the standardization of wasabi supplements is currently insufficient and not well-documented.

What Is Wasabi Typically Used For?

Wasabi has been explored for potential applications in cardiovascular disease prevention, dyspepsia, irritable bowel syndrome, and osteoporosis. Recent studies suggest wasabi may help support cognition/memory. However, reliable evidence for its effectiveness in these areas is currently lacking, and more research is needed.

Drugs that interact with Wasabi

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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