Honey - Acetaminophen, Phenylephrine, Chlorpheniramine Interaction
Herbal: Honey
Also Known As: Beri honey, Blossom Honey, Buckwheat Honey, Chestnut Honey, Clarified Honey, Honeydew Honey, Honig, Jellybush Honey, Madhu, Manuka Honey, Medihoney, Mel, Miel, Purified Honey, Strained Honey, Tualang Honey
Drug: Acetaminophen, Phenylephrine, Chlorpheniramine
Brand names:
Super Cold Tabs
![](https://hellopharmacist.nyc3.digitaloceanspaces.com/images/OBrXo3ni0aNq6p1xr8LXWNogoaVtCExyhTj9MEzw.jpg)
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 16, 2024
Interaction Details
Acetaminophen, Phenylephrine, Chlorpheniramine is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272.
- Fetzner, L., Burhenne, J., Weiss, J., Völker, M., Unger, M., Mikus, G., and Haefeli, W. E. Daily honey consumption does not change CYP3A activity in humans. J Clin Pharmacol 2011;51(8):1223-1232.
Honey Overview
![Honey](https://hellopharmacist.nyc3.digitaloceanspaces.com/images/herbals/width_250/mtSRJ33qg7xwC7h2hSWGtASaKltHuHpUSKTS6Ejo.jpg)
Honey - More Interactions
Honey interacts with 712 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.