Humann Superbeets Heart Chews - Tekturna (Aliskiren) Interaction

Interaction Details

Aliskiren is classified as belonging to the following category: Antihypertensive Drugs

Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews). Beetroot is rich in nitrates, which have the potential to widen blood vessels (vasodilation) and, in turn, possibly lower blood pressure. While there is a theoretical concern about the nitrate content in beets causing a blood pressure drop, research consistently indicates that any impact is generally minor and short-lived. However, it's crucial to be aware that blood pressure medications alone can cause dizziness and lightheadedness. Combining them with beet supplements might heighten the risk of experiencing these side effects due to the temporary vasodilation caused by the nitrates in beet.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

Pharmacist Analysis

As stated in the interaction detail section above, the blood pressure-lowering effects of the nitrates found in beet supplements tend to only be temporary.

However, I would still counsel individuals who are taking blood pressure medications to be cautious if they are considering taking a beet supplement.

Blood pressure medications can cause individuals to feel lightheaded and dizzy. These effects could be more pronounced when combined with a beet supplement, which could increase the risk of falls.

References

• All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans. PubMed
• Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial.PubMed
• The effect of beetroot inorganic nitrate supplementation on cardiovascular risk factors: A systematic review and meta-regression of randomized controlled trials. PubMed

Interaction Details

Aliskiren is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

It is unlikely that grape seed extracts have a clinically significant interaction with drugs that are metabolized by CYP3A4. This effect has only been seen in lab studies and has not been seen in human ones.

Nevertheless, it may be worthwhile to know if the drug you are taking (such as the one in this interaction detail page) is metabolized by CYP3A4 and monitor yourself accordingly.

References

• An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. PubMed
• Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. PubMed
  

Aliskiren Overview

• Aliskiren is used alone or in combination with some medications to treat high blood pressure. Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently.

• High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Humann Superbeets Heart Chews - More Interactions

Humann Superbeets Heart Chews interacts with 848 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.