Manchurian Thorn - Isoniazid Interaction Details

Interaction Details

Isoniazid is classified as belonging to the following category: Hepatotoxic Drugs

Animal research suggests that high doses of Manchurian thorn can induce liver damage. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

Burgos R, Hancke J, Caceres DD, et al. Hepatotoxic effect of Aralia mandshurica dried root extract in pigs. Phytotherapy Res 1997;11(1):59-61.
Burgos R, Hancke J, Wikman G, et al. Toxicological assessment of Aralia mandshurica (Araliaceae) root extract after subchronic administration in rats. A biochemical and histological study. Phytotherapy Res 1994;8(1):1-9.

Isoniazid Overview

Isoniazid is used with other drugs to treat tuberculosis (TB; a serious infection that affects the lungs and sometimes other parts of the body). Isoniazid is also used with other drugs to treat people with latent (resting or nongrowing) TB including those in close contact with people who have active TB, a positive tuberculin skin test, human immunodeficiency virus (HIV), and those with pulmonary fibrosis (scarring of the lungs with an unknown cause). Isoniazid is in a class of medications called antituberculosis agents. It works by killing the bacteria that cause tuberculosis.

See More Information Regarding Isoniazid

Manchurian Thorn - More Interactions

Manchurian Thorn interacts with 413 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.