Miracle Fruit - Xultophy 100/3.6 (Insulin Degludec, Liraglutide) Interaction
Herbal: Miracle Fruit
Also Known As: Synsepalum dulcificum, Bumelia dulcifica, Richadellla dulcifica, Sideroxylon dulcificum, Agbayun, Fruit Miracle, Magic Berry, Miracle Berry, Miraculin, Miraculous Berry, Sweet Berry
Drug: Insulin Degludec, Liraglutide
Brand names:
Xultophy 100/3.6
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Insulin Degludec, Liraglutide is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia. Evidence from an animal model shows that miracle fruit leaf increases insulin production and lowers fasting blood glucose and HbA1c in rats with streptozotocin-induced diabetes. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Obafemi TO, Olaleye MT, Akinmoladun AC. Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate
Miracle Fruit Overview
Miracle fruit, also known as synsepalum dulcificum, is a small red berry native to West Africa. The active ingredient in the berry, called miraculin, temporarily alters the taste buds on the tongue, making sour and acidic foods taste sweet. Due to the effects of miraculin, it is sometimes used as a sugar substitute for people with diabetes or for those looking to reduce their sugar intake. The effects of miraculin can last for up to an hour after consumption. In addition to its use as a natural medicine, miracle berry is also commonly used as a novelty product (e.g., 'mberry miracle berry tablets'), promoted as a fun addition to parties and gatherings, where it is often used as part of a “flavor tripping” experience, where people consume sour and acidic foods, such as lemons or vinegar, and experience the change in taste sensation.
Miracle Fruit - More Interactions
Miracle Fruit interacts with 84 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main herbal interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist