Mommy's Bliss Gripe Water - Aleve PM (Diphenhydramine Hydrochloride, Naproxen Sodium) Interaction
Herbal: Mommy's Bliss Gripe Water
Drug: Diphenhydramine Hydrochloride, Naproxen Sodium
Brand names:
Aleve PM
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Mar 22, 2023
Interaction Details
Diphenhydramine Hydrochloride, Naproxen Sodium is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Mommy's Bliss Gripe Water contains fennel seed and ginger. Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs as animal research suggests that fennel oil has antithrombotic and antiplatelet effects. Ginger is also thought to have mild blood-thinning effects but this has not been demonstrated conclusively in humans, with mixed results from clinical trials. It is important to note that Mommy's Bliss Gripe Water contains only very small quantities of fennel seed and ginger, and clinically significant interactions with blood-thinning drugs are thought to be quite low.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Pharmacist Analysis
Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of ginger and fennel seed ingested by the infant will be between 1mg and 5mg of both.
This small amount is very unlikely to cause a clinically significant interaction with any other drug that thins the blood, but it is important to be aware of it regardless.
References
- Effect of onion and ginger consumption on platelet thromboxane production in humans. PubMed
- The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. PubMed
- [Oral anticoagulants and medicinal plants. An emerging interaction]. PubMed
- Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. PubMed
Mommy's Bliss Gripe Water Overview
Mommy's Bliss Gripe Water is an over-the-counter product used to soothe colicky babies and infants. It is important to note that 'Gripe water' has been used traditionally since at least the 1800s to help treat colic and gastrointestinal discomfort in infants but 'gripe water' is not a standardized formula. Generally, it is a liquid made from a combination of water and various herbs, such as ginger, fennel, chamomile, licorice, and cinnamon, among others. Some varieties may also contain alcohol or sugar. Mommy's Bliss Gripe water contains fennel seed and ginger. It does not contain sugar or alcohol.
Mommy's Bliss Gripe Water - More Interactions
Mommy's Bliss Gripe Water interacts with 765 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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