Mommy's Bliss Gripe Water - Progesterone Interaction
Herbal: Mommy's Bliss Gripe Water
Drug: Progesterone
Brand names:
Milprosa
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Mar 22, 2023
Interaction Details
Progesterone is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Pharmacist Analysis
Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of fennel seed ingested by the infant will be between 1mg and 5mg.
This small amount is very unlikely to cause a clinically significant interaction with any other drug that is metabolized via CYP3A4.
Nevertheless, the theoretical interaction is that fennel, by decreasing the activity of this enzyme, could increase the concentrations of drugs metabolized by it.
The interaction is important to be aware of but will likely not cause any issues.
References
- Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. PubMed
- Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. PubMed
Mommy's Bliss Gripe Water Overview
Progesterone Overview
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Progesterone is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy (surgery to remove the uterus). Hormone replacement therapy usually includes estrogen, which is used to treat symptoms of menopause and reduce the risk of developing certain diseases. However, estrogen can also cause abnormal thickening of the lining of the uterus and increase the risk of developing uterine cancer. Progesterone helps to prevent this thickening and decreases the risk of developing uterine cancer. Progesterone is also used to bring on menstruation (period) in women of childbearing age who have had normal periods and then stopped menstruating. Progesterone is in a class of medications called progestins (female hormones). It works as part of hormone replacement therapy by decreasing the amount of estrogen in the uterus. It works to bring on menstruation by replacing the natural progesterone that some women are missing.
Mommy's Bliss Gripe Water - More Interactions
Mommy's Bliss Gripe Water interacts with 765 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.