Mommy's Bliss Gripe Water - Testosterone Undecanoate Interaction

Interaction Details

Testosterone Undecanoate is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of fennel seed ingested by the infant will be between 1mg and 5mg.

This small amount is very unlikely to cause a clinically significant interaction with any other drug that is metabolized via CYP3A4.

Nevertheless, the theoretical interaction is that fennel, by decreasing the activity of this enzyme, could increase the concentrations of drugs metabolized by it.

The interaction is important to be aware of but will likely not cause any issues.

References

• Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. PubMed
• Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. PubMed

Testosterone Undecanoate Overview

• Testosterone cypionate (Depo-Testosterone), testosterone enanthate (Xyosted, available generically), testosterone undecanoate (Aveed), and testosterone pellet (Testopel) are forms of testosterone injection used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. Your doctor will order certain lab tests to check your testosterone levels to see if they are low before you begin to use testosterone injection. Testosterone enanthate (available generically) and testosterone pellet (Testopel) are also used to stimulate puberty in males with delayed puberty. Testosterone enanthate (available generically) injection may be used in certain women with a type of breast cancer called mammary cancer that has spread to other parts of the body. Testosterone should not be used to treat the symptoms of low testosterone in men who have low testosterone due to aging ('age related hypogonadism'). Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone injection works by supplying synthetic testosterone to replace the testosterone that is normally produced naturally in the body. When used to treat breast cancer, testosterone works by stopping the release of estrogen.

Mommy's Bliss Gripe Water - More Interactions

Mommy's Bliss Gripe Water interacts with 765 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.