Neem - Synjardy (Empagliflozin, Metformin) Interaction
Herbal: Neem
Also Known As: Azadirachta indica, Arishta, Arishtha, Bead Tree, Holy Tree, Huile de Neem, Indian Lilac, Indian Neem, Lilas des Indes, Lilas de Perse, Margosa, Margosa Tree, Margousier, Margousier à Feuilles de Frêne, Margousier d'Inde, Neem Oil, Neem Tree, Nim, Nimb, Nimba, Persian Lilac
Drug: Empagliflozin, Metformin
Brand names:
Synjardy
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Empagliflozin, Metformin is classified as belonging to the following category: Antidiabetes Drugs
Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that neem can lower blood glucose levels in adults with type 2 diabetes, including those already taking metformin.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82:1336-45.
- Pingali U, Ali MA, Gundagani S, Nutalapati C. Evaluation of the effect of an aqueous extract of Azadirachta indica (neem) leaves and twigs on glycemic control, endothelial dysfunction and systemic inflammation in subjects with type 2 diabetes mellitus - a
Neem Overview
Neem (Azadirachta indica) is a tree native to India and is widely cultivated in tropical and subtropical regions around the world. The leaves, seeds, and bark of the neem tree are often used in herbal remedies and are thought to have antioxidant, anti-inflammatory, and antimicrobial properties.
Neem is used in traditional medicine to treat a variety of conditions, including skin conditions, digestive disorders, respiratory problems, and fever. It is also used as a natural remedy for anxiety, stress, and other ailments. Additionally, it has been used in aromatherapy to improve mood and reduce stress.
The leaves of the tree are used as a natural pesticide and are believed to be effective at controlling a variety of pests, including insects, nematodes, and fungi. It is approved for use as a pesticide in the United States by the Environmental Protection Agency (EPA).
Neem - More Interactions
Neem interacts with 901 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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