Passion Flower - Zyloprim (Allopurinol) Interaction
Herbal: Passion Flower
Also Known As: Passiflora incarnata, Apricot Vine, Burucuya, Granadilla, Grandilla, Maracuja, Maracuya, Maypop, Pasiflora, Pasionari, Pasionaria, Passiflora, Passiflore, Passiflorina, Passion Vine, Passionaria, Passionblume, Passionflower, Passionflower Herb, Passionsblomma, Water Lemon
Drug: Allopurinol
Brand names:
Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 16, 2024
Interaction Details
There were no interactions found between Allopurinol and Passion Flower. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Passionflower is not known to have many clinically significant drug interactions.
Nevertheless, it has been shown to have sedative effects, which can be additive when used in conjunction with sedative medications (e.g., Benadryl, benzodiazepines, opioids, etc...).
Therefore, we do list interactions between Passionflower and CNS (central nervous system) depressants or other drugs with strong sedative effects.
Additionally, certain constituents of Passionflower (such as apigenin and vitexin) may inhibit certain drug transports, specifically OATP2B1 and OATP1A2.
These are responsible for the uptake of certain drugs and other compounds into the body.
As Passionflower can inhibit these transports, it is possible that it might reduce the bioavailability of drugs that are substrates for these transporters but studies are far from conclusive on the matter.
There is no known drug interaction between Passionflower and the drug in question here, however.
As always, be sure to speak with your doctor before making any changes to your medication regimen.
- Dr. Brian Staiger, PharmDPassion Flower Overview
Allopurinol Overview
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Allopurinol is used to treat gout (a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints and causes sudden attacks of redness, swelling, pain, and heat in one or more joints). Allopurinol is also used to treat high levels of uric acid that builds up in the blood as tumors break down in people with certain types of cancer who are being treated with chemotherapy medications. It is also used to treat kidney stones that have come back in people who have high levels of uric acid in their urine. Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Allopurinol is used to prevent gout attacks, not to treat them once they occur.
Passion Flower - More Interactions
Passion Flower interacts with 814 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.