Rooibos - Pariet (Rabeprazole) Interaction
Herbal: Rooibos
Also Known As: Aspalathus linearis, Green Red Bush, Infusion Rooibos, Kaffree Tea, Red Bush, Red Bush Tea, Rooibos Rouge, Rooibos Tea, Té Rojo, Té Rojo Rooibos, Thé Rooibos, Thé Rouge
Drug: Rabeprazole
Brand names:
Pariet
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Rabeprazole is classified as belonging to the following category: Cytochrome P450 2C19 (Cyp2C19) Substrates
Rooibos might increase the concentration and the effects of cytochrome P450 2C19 (CYP2C19) substrates. In vitro research shows that the methanol extract of rooibos leaves and stems strongly inhibits CYP2C19 enzymes.
Some drugs metabolized by CYP2C19 include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin, and many others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Fantoukh OI, Dale OR, Parveen A, et al. Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea (Aspalathus linearis) through Interaction with CYP, PXR, and P-gp. J Agric Food Chem. 2019;67(17):4967-4975.
Interaction Details
Rabeprazole is classified as belonging to the following category: Cytochrome P450 2C9 (Cyp2C9) Substrates
Rooibos might increase the concentration and the effects of cytochrome P450 2C9 (CYP2C9) substrates. In vitro research shows that the methanol extract of rooibos leaves and stems inhibits CYP2C9 enzymes.
Some substrates of CYP2C9 include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Fantoukh OI, Dale OR, Parveen A, et al. Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea (Aspalathus linearis) through Interaction with CYP, PXR, and P-gp. J Agric Food Chem. 2019;67(17):4967-4975.
Interaction Details
Rabeprazole is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Rooibos might increase the concentration and the effects of cytochrome P450 3A4 (CYP3A4) substrates. In vitro research shows that the methanol extract of rooibos leaves and stems strongly inhibits CYP3A4 enzymes.
Some drugs metabolized by CYP3A4 include atorvastatin (Lipitor), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), midazolam (Versed), and many others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Fantoukh OI, Dale OR, Parveen A, et al. Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea (Aspalathus linearis) through Interaction with CYP, PXR, and P-gp. J Agric Food Chem. 2019;67(17):4967-4975.
- Patel O, Muller CJF, Joubert E, et al. Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats. Front Pharmacol. 2019;10:1243.
Rooibos Overview
Rooibos is a plant that is native to South Africa. The leaves and stems of the rooibos plant are used to make a tea, which has a unique, slightly sweet flavor and is known for its soothing properties. It is caffeine-free and high in antioxidants.
Rooibos tea has been used in traditional medicine for the treatment of age-related cognitive decline, hay fever, anxiety, cardiovascular disease (CVD), diabetes, gastrointestinal disorders, inflammatory conditions and obesity. Research of rooibos extracts indicate it contains over 187 different compounds, some of which may have medicinal effects.
Rabeprazole Overview
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Rabeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube that connects the throat and stomach) in adults and children 12 year of age and older. Rabeprazole is used to treat damage from GERD, allow the esophagus to heal, and prevent further damage to the esophagus in adults. Rabeprazole is also used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults. Rabeprazole is used to treat ulcers (sores in the lining of the stomach or intestine) and is used in combination with other medications to eliminate H. pylori (a bacteria that causes ulcers) in adults. Rabeprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.
Rooibos - More Interactions
Rooibos interacts with 834 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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