Interaction Details

There were no interactions found between Doxylamine Succinate and Same. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Doxylamine Succinate and Same? Ask Dr. Brian Staiger about it by contacting him directly.

Same Overview

Same S-adenosyl-l-methionine (SAM-e or SAMe) is a compound that is found naturally in the body and is involved in various processes, including the synthesis of neurotransmitters and the metabolism of hormones. SAM-e has been studied as a potential treatment for a variety of health conditions, including depression, osteoarthritis, and liver disease. As a dietary supplement, it is most often used for improving symptoms of depression and for osteoarthritis. In regard to depression, research suggests that SAM-e may be more effective than placebo in reducing the severity of depression and may be as effective as certain antidepressants for some individuals. However, more research is needed. Similarly, for osteoarthritis, some studies show that it is as effective in reducing symptoms for some individuals as NSAIDs (e.g., ibuprofen). There are a variety of different forms of SAM-e supplements available on the market, typically different salt forms (e.g., sulfate, sulfate-p-toluenesulfonate, and butanedisulfonate), which may affect how well it is absorbed.
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Doxylamine Succinate Overview

  • Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication.

  • Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

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Same - More Interactions

Same interacts with 186 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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