Dextromethorphan Interactions

Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing.

See More information Regarding Dextromethorphan

Brand Names Associated with Dextromethorphan

  • Alka-Seltzer Plus Cold and Cough Formula® (as a combination product containing Aspirin, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • Alka-Seltzer Plus Day and Night Cold Formulas® (as a combination product containing Aspirin, Dextromethorphan, Phenylephrine)
  • Alka-Seltzer Plus Day Non-Drowsy Cold Formula® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
  • Alka-Seltzer Plus Flu Formula® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • Alka-Seltzer Plus Mucus and Congestion® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Alka-Seltzer Plus Night Cold Formula® (as a combination product containing Aspirin, Dextromethorphan, Doxylamine, Phenylephrine)
  • Children's Dimetapp Cold and Cough® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
  • Children's Dimetapp Multisymptom Cold and Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • Children's Mucinex Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Children's Mucinex Multi-Symptom Cold® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
  • Children's Robitussin Cough and Cold CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
  • Children's Robitussin Cough and Cold Long-Acting® (as a combination product containing Chlorpheniramine, Dextromethorphan)
  • Children's Sudafed PE Cold and Cough® (as a combination product containing Dextromethorphan, Phenylephrine)
  • Coricidin HBP Chest Congestion and Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Coricidin HBP Cough and Cold® (as a combination product containing Chlorpheniramine, Dextromethorphan)
  • Coricidin HBP Day and Night Multi-Symptom Cold® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Guaifenesin)
  • Coricidin HBP Maximum Strength Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
  • Coricidin HBP Nighttime Multi-Symptom Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
  • Delsym 12-hour Cough
  • Dextromethorphan
  • Diabetic Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Dimetane DX® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • DM
  • Mucinex Cough for Kids® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Mucinex DM® (as a combination product containing Dextromethorphan, Guaifenesin)
  • PediaCare Children's Cough and Congestion® (as a combination product containing Dextromethorphan, Guaifenesin)
  • PediaCare Children's Fever Reducer Plus Cough and Runny Nose® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
  • PediaCare Children's Fever Reducer Plus Cough and Sore Throat® (as a combination product containing Acetaminophen, Dextromethorphan)
  • PediaCare Children's Fever Reducer Plus Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • PediaCare Children's Fever Reducer Plus Multi-Symptom Cold® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • Robitussin Cough and Chest DM® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Robitussin Cough and Cold CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
  • Robitussin Cough and Cold Long-Acting® (as a combination product containing Chlorpheniramine, Dextromethorphan)
  • Robitussin Cough Long-Acting®
  • Robitussin Night Time Cough, Cold, and Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • Sudafed PE Cold/Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
  • Sudafed PE Day/Night Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Diphenhydramine, Guaifenesin, Phenylephrine)
  • Theraflu Cold and Cough® (as a combination product containing Dextromethorphan, Pheniramine, Phenylephrine)
  • Theraflu Daytime Severe Cold and Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
  • Theraflu Max-D Severe Cold and Flu® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • Triaminic Cough and Sore Throat® (as a combination product containing Acetaminophen, Dextromethorphan)
  • Triaminic Day Time Cold and Cough® (as a combination product containing Dextromethorphan, Phenylephrine)
  • Triaminic Long-Acting Cough®
  • Triaminic Multi-Symptom Fever® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
  • Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
  • Tylenol Cold and Cough Daytime® (as a combination product containing Acetaminophen, Dextromethorphan)
  • Tylenol Cold and Cough Nighttime® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
  • Tylenol Cold and Flu Severe® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
  • Tylenol Cold and Mucus Severe® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
  • Tylenol Cold Multi-Symptom Nighttime® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
  • Vicks Children's NyQuil Cold and Cough® (as a combination product containing Chlorpheniramine, Dextromethorphan)
  • Vicks DayQuil Cold and Flu Relief® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
  • Vicks DayQuil Cold and Flu Symptom Relief Plus Vitamin C® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
  • Vicks DayQuil Cough®
  • Vicks DayQuil Mucus Control DM® (as a combination product containing Dextromethorphan, Guaifenesin)

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The drugs below are categorized by the severity of their interaction (see description of categories at the bottom of the page).

Click the drug name (listed by the generic name) to view specific drug-drug interaction details.
Navigate: Contraindicated | Major | Moderate

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What Do The Severity Ratings Mean?

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Drug interaction information is compilated from several drug compendia, including:

  • Gold Standard Drug Database
  • Micromedix
  • Lexicomp
  • PubMed

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.