Amiodarone with Deferasirox Interaction Details
Brand Names Associated with Amiodarone
- Amiodarone
- Cordarone®
- Pacerone®
Brand Names Associated with Deferasirox
- Deferasirox
- Exjade®
- Jadenu®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 27, 2024
Interaction Effect
Altered exposure of amiodarone
Interaction Summary
Amiodarone is primarily metabolized by CYP3A and CYP2C8[1]. Deferasirox may induce CYP3A4, resulting in decreased concentrations of a CYP3A4 substrate and deferasirox can inhibit CYP2C8, resulting in increased exposure to a CYP2C8 substrate [2]. Coadministration of amiodarone with a CYP2C8 inhibitor should be avoided, as exposure to amiodarone may be increased. Due to the long half-life of amiodarone, drug interactions may persist for weeks to months after discontinuation [1]. If coadministration is required, consider monitoring for reduced effectiveness or increased exposure-related toxicities [2].
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Amiodarone is primarily metabolized by CYP3A and CYP2C8[1]. Deferasirox may induce CYP3A4, resulting in decreased concentrations of a CYP3A4 substrate and deferasirox can inhibit CYP2C8, resulting in increased exposure to a CYP2C8 substrate [2]. Coadministration of amiodarone with a CYP2C8 inhibitor should be avoided, as exposure to amiodarone may be increased. Due to the long half-life of amiodarone, drug interactions may persist for weeks to months after discontinuation [1]. If coadministration is required, consider monitoring for reduced effectiveness or increased exposure-related toxicities [2].
Mechanism Of Interaction
Reduced CYP2C8-mediated metabolism of amiodarone; increased CYP3A-mediated metabolism of amiodarone
References
1 ) Product Information: CORDARONE(R) oral tablets, amiodarone oral tablets. Wyeth Pharmaceuticals Inc (per FDA), Philadephia, PA, 2018.
2 ) Product Information: JADENU(R) oral tablets, deferasirox oral tablets. Novartis Pharmaceuticals Corporation (per manufacturer), East Hanover, NJ, 2018.
Amiodarone Overview
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Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. Amiodarone is in a class of medications called antiarrhythmics. It works by relaxing overactive heart muscles.
Deferasirox Overview
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Deferasirox is used to treat adults and children 2 years of age and older who have too much iron in their body because they received many blood transfusions. It is also used to treat adults and children 10 years of age and older who have too much iron in their body because of a genetic blood disorder called non–transfusion-dependent thalassemia (NTDT). Deferasirox is in a class of medications called iron chelators. It works by attaching to iron in the body so that it can be excreted (removed from the body) in feces.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.