Amitriptyline with Mirabegron Interaction Details
Brand Names Associated with Amitriptyline
- Amitid®
- Amitril®
- Amitriptyline
- Duo-Vil® (as a combination product containing Amitriptyline, Perphenazine)
- Elavil®
- Endep®
- Etrafon® (as a combination product containing Amitriptyline, Perphenazine)
- Limbitrol® (as a combination product containing Amitriptyline, Chlordiazepoxide)
- Triavil® (as a combination product containing Amitriptyline, Perphenazine)
Brand Names Associated with Mirabegron
- Mirabegron
- Myrbetriq®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 03, 2023
Interaction Effect
Increased amitriptyline exposure
Interaction Summary
Patients concurrently treated with mirabegron, a moderate CYP2D6 inhibitor, and amitriptyline, a CYP2D6 substrate , may have an increase in amitriptyline exposure and risk of adverse events. Concomitant use of tricyclic antidepressants with CYP2D6 inhibitors may require lower doses for either the tricyclic antidepressant or the CYP2D6 inhibitor; monitoring of the tricyclic antidepressant is recommended .
Severity
Moderate
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Concomitant use of mirabegron, a moderate CYP2D6 inhibitor, and amitriptyline, a CYP2D6 substrate , may result in increased amitriptyline exposure. Concomitant use of tricyclic antidepressants with CYP2D6 inhibitors may require lower doses for either the tricyclic antidepressant or the CYP2D6 inhibitor; monitoring of the tricyclic antidepressant is recommended .
Mechanism Of Interaction
Inhibition of CYP2D6-mediated amitriptyline metabolism by mirabegron
Amitriptyline Overview
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Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.
Mirabegron Overview
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Mirabegron is used alone or in combination with solifenacin (Vesicare) to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in adults. It is also used to treat neurogenic detrusor overactivity (a bladder control condition caused by brain, spinal cord or nerve problem) in children 3 years of age and older. Mirabegron is in a class of medications called beta-3 adrenergic agonists. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.