Amlodipine with Epirubicin Interaction Details
Brand Names Associated with Amlodipine
- Amlodipine
- Amvaz®
- Azor® (as a combination product containing Amlodipine, Olmesartan)
- Caduet® (as a combination product containing Amlodipine, Atorvastatin)
- Consensi® (as a combination product containing Amlodipine, Celecoxib)
- Exforge® (as a combination product containing Amlodipine, Valsartan)
- Exforge® HCT (as a combination product containing Amlodipine, Hydrochlorothiazide, Valsartan)
- Katerzia®
- Norvasc®
- Prestalia® (as a combination product containing Amlodipine, Perindopril)
- Tribenzor® (as a combination product containing Amlodipine, Hydrochlorothiazide, Olmesartan)
- Twynsta® (as a combination product containing Amlodipine, Telmisartan)
Brand Names Associated with Epirubicin
- Ellence®
- Epirubicin
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Mar 03, 2024
Interaction Effect
Increased risk of heart failure
Interaction Summary
Epirubicin may cause delayed cardiac toxicity and concomitant use of epirubicin with other cardioactive compounds that could cause heart failure (eg, calcium channel blockers) requires close monitoring of cardiac function throughout treatment[1]. The AUC of epirubicin metabolites was increased with concurrent verapamil therapy in a study of 10 patients, which may cause increased cardiotoxicity [2]; however, a randomized phase II trial if 51 patients demonstrated no difference in efficacy or toxicity with the combination compared with epirubicin alone [3].
Severity
Major
Onset
Delayed
Evidence
Theoretical
How To Manage Interaction
Epirubicin may cause delayed cardiac toxicity and concomitant use of other cardioactive compounds that could cause heart failure (eg, calcium channel blockers) requires close monitoring of cardiac function throughout treatment[1].
Mechanism Of Interaction
Not specified
Literature Reports
A) The AUC of epirubicin metabolites was increased with concurrent verapamil therapy in a study of 10 patients with advanced breast cancer. Suggested mechanisms for these altered metabolite values were enzyme induction, increased liver blood flow, or reduced plasma clearance associated with the presence of verapamil [2].
References
1 ) Product Information: ELLENCE(R) intravenous injection , epirubicin HCl intravenous injection . Pharmacia & Upjohn Co (per FDA) , New York, NY, 2019.
2 ) Mross K, Hamm K, & Hossfeld DK: Effects of verapamil on the pharmacokinetics and metabolism of epirubicin. Cancer Chemother Pharmacol 1993; 31:369-375.
3 ) Mross K, Bohn L, Edler W, et al: Randomized phase II study of single-agent epirubicin +/- verapamil in patients with advanced metastatic breast cancer. An AIO clinical trial. Arbeitsgemeinschaft Internistische Onkologie of the German Cancer Society. Ann Oncol 1993a; 4(1):45-50.
Amlodipine Overview
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Amlodipine is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years and older. It is also used to treat certain types of angina (chest pain) and coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Amlodipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood to the heart. If taken regularly, amlodipine controls chest pain, but it does not stop chest pain once it starts. Your doctor may prescribe a different medication to take when you have chest pain.
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High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Epirubicin Overview
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Epirubicin is used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. Epirubicin is in a class of medications called anthracyclines. It works by slowing or stopping the growth of cancer cells in your body.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.