Buspirone with Nefazodone Interaction Details
Brand Names Associated with Buspirone
- BuSpar®
- Buspirone
Brand Names Associated with Nefazodone
- Nefazodone
- Serzone®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Mar 06, 2024
Interaction Effect
Increased busPIRone plasma concentrations
Interaction Summary
Concomitant administration of busPIRone 2.5 mg or 5 mg twice daily and nefazodone 250 mg twice daily resulted in large increases in the busPIRone plasma concentration in healthy volunteers. Maximum concentration (Cmax) was increased up to 20-fold and the area under the concentration-time curve (AUC) was elevated by as much as 50-fold. In addition, plasma concentrations of 1-PP, a busPIRone metabolite, were decreased by 50%. If concomitant administration of busPIRone and nefazodone is necessary, low doses of busPIRone (2.5 mg twice daily) should be utilized and further dosing adjustments should be based on clinical assessment[1][2].
Severity
Moderate
Onset
Rapid
Evidence
Probable
How To Manage Interaction
Nefazodone should be avoided in patients treated with busPIRone. If this combination cannot be avoided, low doses of busPIRone (2.5 mg twice daily) should be used. Monitor the patient for side effects of busPIRone.
Mechanism Of Interaction
Inhibition by nefazodone of cytochrome P450 3A4-mediated metabolism of busPIRone
References
1 ) Product Information: Serzone(R), nefazodone. Bristol-Myers Squibb Company, Princeton, NJ, 2002.
2 ) Product Information: BuSpar(R), buspirone. Bristol-Myers Squibb Company, Princeton, NJ, 1998.
Buspirone Overview
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Buspirone is used to treat anxiety disorders or in the short-term treatment of symptoms of anxiety. Buspirone is in a class of medications called anxiolytics. It works by changing the amounts of certain natural substances in the brain.
Nefazodone Overview
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Nefazodone is used to treat depression. Nefazodone is in a class of medications called serotonin modulators. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.