Carbamazepine with Cobicistat Interaction Details
Brand Names Associated with Carbamazepine
- Carbamazepine
- Carbatrol®
- Epitol®
- Equetro®
- Tegretol®
- Tegretol®-XR
- Teril®
Brand Names Associated with Cobicistat
- Cobicistat
- Tybost®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 25, 2023
Interaction Effect
Reduced cobicistat exposure, reduced efficacy of cobicistat and possible viral resistance and an increased carBAMazepine exposure
Interaction Summary
Concurrent use of carBAMazepine, a potent inducer of CYP3A4 and a CYP3A4 substrate, with cobicistat, a CYP3A substrate and CYP3A inhibitor, is contraindicated due to the potential for decreased cobicistat plasma concentrations and development of resistance. The coadministration of cobicistat plus elvitegravir with carBAMazepine caused an increase in carBAMazepine Cmax by 40% and AUC by 43% .
Severity
Contraindicated
Onset
Unspecified
Evidence
Established
How To Manage Interaction
Concurrent use of carBAMazepine and cobicistat is contraindicated due to the potential for decreased cobicistat plasma concentrations and/or increased concentrations of carBAMazepine. Reduced virologic response and possible viral resistance and/or increased carBAMazepine side effects may occur.
Mechanism Of Interaction
Induction of CYP3A-mediated metabolism of cobicistat by carBAMazepine; inhibition of CYP3A-mediated carBAMazepine metabolism by cobicistat
Literature Reports
A) In a drug interaction pharmacokinetic study, coadministration of carBAMazepine 200 mg twice daily with elvitegravir/cobicistat 150 mg/150 mg once daily resulted in a mean ration of carBAMazepine AUC and Cmax of 1.43 (90% CI, 1.36 to 1.52) and 1.4 (90% CI, 1.32 to 1.49) respectively and carBAMazepine-10,11 epoxide AUC and Cmax of 0.65 (90% CI, 0.63 to 0.66) and 0.73 (90% CI, 0.7 to 0.78) respectively .
Carbamazepine Overview
-
Carbamazepine is used alone or in combination with other medications to control certain types of seizures in people with epilepsy. It is also used to treat trigeminal neuralgia (a condition that causes facial nerve pain). Carbamazepine extended-release capsules (Equetro brand only) are also used to treat episodes of mania (frenzied, abnormally excited or irritated mood) or mixed episodes (symptoms of mania and depression that happen at the same time) in patients with bipolar I disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Carbamazepine is in a class of medications called anticonvulsants. It works by reducing abnormal electrical activity in the brain.
Cobicistat Overview
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Cobicistat is used to increase the amounts of atazanavir (Reyataz, in Evotaz ) in adults and children weighing at least 77 pounds (35 kg) or darunavir (Prezista, in Prezcobix ) in adults and children weighing at least 88 pounds (40 kg) in the blood when these medications are used to treat human immunodeficiency virus (HIV). Cobicistat is in a class of medications called pharmacokinetic boosters. It works by increasing the amount of atazanavir or darunavir in the body so that they can have a greater effect.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.