Cobicistat

Generic name: Pronounced as (koe bik' i stat)
Brand names
  • Tybost®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

Cobicistat is used to increase the amounts of atazanavir (Reyataz, in Evotaz ) in adults and children weighing at least 77 pounds (35 kg) or darunavir (Prezista, in Prezcobix ) in adults and children weighing at least 88 pounds (40 kg) in the blood when these medications are used to treat human immunodeficiency virus (HIV). Cobicistat is in a class of medications called pharmacokinetic boosters. It works by increasing the amount of atazanavir or darunavir in the body so that they can have a greater effect.

Cobicistat comes as a tablet to take by mouth. It is usually taken with food once a day along with atazanavir or darunavir. Take cobicistat with atazanavir or darunavir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cobicistat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

It is important to always take cobicistat at the same time as atazanavir or darunavir.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking cobicistat,

  • tell your doctor and pharmacist if you are allergic to cobicistat, any other medications, or any of the ingredients in cobicistat tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor if you are taking any of the following medications: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid) (not available in the U.S.); colchicine (Colcrys, Mitigare, in Col-Probenecid); dronedarone (Multaq); ergot medications such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Versed) by mouth; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, in Rifamate, in Rifater); sildenafil (only Revatio brand used for lung disease); simvastatin (Flolipid, Zocor); St. John's wort; or triazolam (Halcion). If you are taking atazanavir along with cobicistat, tell your doctor if you are taking drospirenone and ethinyl estradiol (certain oral contraceptives such as Beyaz, Safyral, Yasmin, Yaz, others); indinavir (Crixivan), irinotecan (Camptosar), or nevirapine (Viramune). Your doctor will probably tell you not to take cobicistat if you are taking any of these medications.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as apixaban (Eliquis), betrixaban (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban (Xarelto), and warfarin (Coumadin, Jantoven); antiplatelet medications such as clopidogrel (Plavix) and ticagrelor (Brilinta); atorvastatin (Lipitor, in Caduet); benzodiazepines such as diazepam (Valium), estazolam, midazolam given intravenously (into a vein), and zolpidem (Ambien, Edluar, Intermezzo); beta blockers such as carvedilol (Coreg), metoprolol (Lopressor), and timolol; boceprevir (Victrelis) (not available in the U.S.); bosentan (Tracleer); buprenorphine (Belbuca, Butrans, Probuphine); buprenorphine and naloxone (Suboxone, Zubsolv); buspirone; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nifedipine (Adalat, Afeditab, Procardia), and verapamil (Calan, Verelan, others); clarithromycin (Biaxin, in PrevPac); corticosteroids such as beclomethasone (Beconase AQ), budesonide (Rhinocort Aqua), ciclesonide (Omnaris), dexamethasone (Decadron), fluticasone (Flonase, Flovent), methylprednisolone (Medrol), momentasone (Flonase), and triamcinolone (Nasacort AQ); dasatinib (Sprycel); efavirenz (Sustiva, in Atripla); erythromycin (E.E.S, Erytab, others); etravirine (Intelence); fentanyl (Abstral, Actiq, Fentora, others); itraconazole (Onmel, Sporanox); ketoconazole; medications for depression such as amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), and trazodone; medications for irregular heartbeat such as amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), and quinidine (in Nuedexta); medications for seizures such as clonazepam (Klonopin), eslicarbazepine (Aptiom), and oxcarbazepine (Trileptal); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), and tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (in Kaletra); maraviroc (Selzentry); methadone (Dolophine, Methadose); nilotinib (Tasigna); oral contraceptives (birth control pills); perphenazine; certain phosphodiesterase (PDE5) inhibitors such as avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); ritonavir (Norvir, in Kaletra); rivaroxaban (Xarelto); rosuvastatin; salmeterol (Serevent, in Advair); simeprevir (Olysio); telaprevir (Incivek) (not available in the U.S.); telithromycin (Ketek); tenofovir (Viread, in Atripla, Complera, Truvada, others), thioridazine; tramadol (Conzip, Ultram, in Ultracet); vinblastine; vincristine (Marqibo Kit); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with cobicistat so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • if you are taking cobicistat with atazanavir and you are also taking antacids (Maalox, Mylanta, Tums, others), take them 2 hours before or 2 hours after cobicistat and atazanavir.

  • if you are taking cobicistat with atazanavir and you are also taking a medication for indigestion, heartburn, or ulcers (H2 blockers) such as cimetidine, famotidine (Pepcid, in Duexis), nizatidine (Axid), or ranitidine (Zantac), take them at the same time or at least 10 hours after taking the H2 blocker.

  • if you are taking cobicistat with atazanavir and you are also taking a medication for indigestion, heartburn, or ulcers (proton pump inhibitors) such as esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, in Zegerid), pantoprazole (Protonix), or rabeprazole (AcipHex) take them at least 12 hours after taking the proton pump inhibitor.

  • tell your doctor if you have or have ever had kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking cobicistat, call your doctor. You should not breastfeed if you are infected with HIV or if you are taking cobicistat.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

It is important that you take cobicistat, and all other medications prescribed by your doctor to treat HIV medication, every day and on a regular schedule. Missed doses may cause the medications to not work as well at treating the infection. Do not stop any of these medications without talking to your doctor.

  • Cobicistat may cause side effects. Tell your doctor if this symptom is severe or does not go away:

    • nausea

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • yellowing of the skin or eyes

    • rash

    • decreased urination

  • Cobicistat may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to cobicistat.

Keep a supply of medication on hand. Do not wait until you run out of medication to refill your prescription.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The excretion of Repaglinide can be decreased when combined with Cobicistat.
Leflunomide Leflunomide Cobicistat may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Cobicistat can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Cobicistat.
Atorvastatin Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Cobicistat.
Dolasetron Dolasetron The metabolism of Dolasetron can be decreased when combined with Cobicistat.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Cobicistat.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Cobicistat.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Cobicistat.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Cobicistat.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Cobicistat may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Cobicistat.
Guanfacine Guanfacine The metabolism of Guanfacine can be decreased when combined with Cobicistat.
Methylergonovine Methylergonovine The serum concentration of Methylergometrine can be increased when it is combined with Cobicistat.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Cobicistat.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Cobicistat.
Prednisone Prednisone The metabolism of Cobicistat can be decreased when combined with Prednisone.
Reserpine Reserpine The metabolism of Cobicistat can be increased when combined with Reserpine.
Sumatriptan Sumatriptan Cobicistat may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Cobicistat.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Cobicistat.
Fluconazole Injection Fluconazole Injection The metabolism of Cobicistat can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Cobicistat.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Methylprednisolone can be decreased when combined with Cobicistat.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be decreased when combined with Cobicistat.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Cobicistat.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Cobicistat.
Zidovudine Injection Zidovudine Injection Cobicistat may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Altretamine Altretamine The metabolism of Amphetamine can be decreased when combined with Cobicistat.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Cobicistat.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Cobicistat.
Torsemide Torsemide The excretion of Torasemide can be decreased when combined with Cobicistat.
Olanzapine Olanzapine The metabolism of Olanzapine can be decreased when combined with Cobicistat.
Dofetilide Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Cobicistat.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Cobicistat.
Oxcarbazepine Oxcarbazepine The metabolism of Cobicistat can be increased when combined with Oxcarbazepine.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Cobicistat.
Anakinra Anakinra The metabolism of Cobicistat can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Cobicistat.
Etanercept Injection Etanercept Injection The metabolism of Cobicistat can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Cobicistat can be increased when combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Cobicistat.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Cobicistat.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Cobicistat.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Cobicistat.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Cobicistat.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Cobicistat.
Adalimumab Injection Adalimumab Injection The metabolism of Cobicistat can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Cobicistat.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Cobicistat.
Ezetimibe Ezetimibe Cobicistat may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Cobicistat.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Cobicistat.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Cobicistat.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Cobicistat.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Cobicistat.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Cobicistat.
Tegaserod Tegaserod Cobicistat may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Tadalafil Tadalafil The serum concentration of Tadalafil can be increased when it is combined with Cobicistat.
Progesterone Progesterone The serum concentration of Progesterone can be decreased when it is combined with Cobicistat.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Cobicistat.
Infliximab Injection Infliximab Injection The metabolism of Cobicistat can be increased when combined with Infliximab.
Protriptyline Protriptyline The metabolism of Protriptyline can be decreased when combined with Cobicistat.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Cobicistat.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Cobicistat.
Norethindrone Norethindrone The serum concentration of Norethisterone can be decreased when it is combined with Cobicistat.
Bosentan Bosentan The serum concentration of Bosentan can be increased when it is combined with Cobicistat.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Cobicistat.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be increased when it is combined with Cobicistat.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Cobicistat.
Voriconazole Voriconazole The metabolism of Cobicistat can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Cobicistat.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Cobicistat.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Cobicistat.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Cobicistat.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Cobicistat.
Abatacept Injection Abatacept Injection The metabolism of Cobicistat can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Cobicistat can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Cobicistat.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Cobicistat.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Cobicistat.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Cobicistat.
Clofarabine Injection Clofarabine Injection Cobicistat may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection Cobicistat may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Cobicistat.
Lisdexamfetamine Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Cobicistat.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Cobicistat.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Cobicistat.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Cobicistat.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Cobicistat.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Cobicistat.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Cobicistat.
Armodafinil Armodafinil The metabolism of Cobicistat can be increased when combined with Armodafinil.
Ivermectin Ivermectin Cobicistat may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Cobicistat.
Maraviroc Maraviroc The metabolism of Maraviroc can be decreased when combined with Cobicistat.
Nilotinib Nilotinib The metabolism of Cobicistat can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Toremifene can be increased when it is combined with Cobicistat.
Budesonide Budesonide The metabolism of Cobicistat can be decreased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Cobicistat can be decreased when combined with Chloramphenicol.
Mitoxantrone Injection Mitoxantrone Injection Cobicistat may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Cobicistat.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Cobicistat.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Cobicistat.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Cobicistat.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Cobicistat.
Certolizumab Injection Certolizumab Injection The metabolism of Cobicistat can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Cobicistat.
Irinotecan Injection Irinotecan Injection The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Cobicistat.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Cobicistat.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Cobicistat.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Cobicistat.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Cobicistat.
Milnacipran Milnacipran The metabolism of Milnacipran can be decreased when combined with Cobicistat.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Cobicistat.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Cobicistat.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Cobicistat.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Cobicistat.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Cobicistat.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Cobicistat.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Cobicistat.
Pralatrexate Injection Pralatrexate Injection Cobicistat may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Cobicistat.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Cobicistat.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Cobicistat.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Cobicistat.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Cobicistat.
Golimumab Injection Golimumab Injection The metabolism of Cobicistat can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Cobicistat.
Pitavastatin Pitavastatin Cobicistat may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Cobicistat.
Ulipristal Ulipristal The serum concentration of Ulipristal can be decreased when it is combined with Cobicistat.
Levonorgestrel Levonorgestrel The serum concentration of Levonorgestrel can be decreased when it is combined with Cobicistat.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Cobicistat.
Tocilizumab Injection Tocilizumab Injection The metabolism of Cobicistat can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Cobicistat.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Cobicistat.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Cobicistat.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Cobicistat.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Cobicistat.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Cobicistat.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Cobicistat.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Cobicistat.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Cobicistat.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Cobicistat.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Cobicistat.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Cobicistat.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Cobicistat.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Cobicistat.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Cobicistat.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Cobicistat.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Cobicistat.
Crizotinib Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Cobicistat.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Cobicistat.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Cobicistat.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Cobicistat.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Cobicistat.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Cobicistat.
Regorafenib Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Cobicistat.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Cobicistat.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Corticotropin can be decreased when combined with Cobicistat.
Teriflunomide Teriflunomide Cobicistat may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Cobicistat.
Bedaquiline Bedaquiline The metabolism of Bedaquiline can be decreased when combined with Cobicistat.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Cobicistat.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Cobicistat.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Cobicistat.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Cobicistat.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Cobicistat.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Cobicistat.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Cobicistat.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Cobicistat.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Cobicistat.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Cobicistat.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Cobicistat.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Cobicistat.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Cobicistat.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Cobicistat.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Cobicistat.
Simeprevir Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Cobicistat.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Cobicistat.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Cobicistat.
Apremilast Apremilast The metabolism of Cobicistat can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Cobicistat.
Siltuximab Injection Siltuximab Injection The metabolism of Cobicistat can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Cobicistat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Cobicistat.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Cobicistat.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Cobicistat.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Cobicistat.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Cobicistat.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Cobicistat.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Cobicistat.
Caspofungin Injection Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Cobicistat.
Methamphetamine Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Cobicistat.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Cobicistat.
Riociguat Riociguat The serum concentration of Riociguat can be increased when it is combined with Cobicistat.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Cobicistat.
Secukinumab Injection Secukinumab Injection The metabolism of Cobicistat can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Cobicistat.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Cobicistat.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Cobicistat.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Cobicistat.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Cobicistat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Cobicistat.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Isavuconazonium can be increased when it is combined with Cobicistat.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Cobicistat.
Flibanserin Flibanserin The metabolism of Flibanserin can be decreased when combined with Cobicistat.
Prednisolone Prednisolone The metabolism of Prednisolone can be decreased when combined with Cobicistat.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Cobicistat.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Cobicistat.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Cobicistat.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Cobicistat.
Eluxadoline Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Cobicistat.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Cobicistat.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Cobicistat.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Cobicistat.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Cobicistat.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Cobicistat.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Cobicistat can be decreased when it is combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Cobicistat.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Cobicistat.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Cobicistat.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Cobicistat.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Cobicistat.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Cobicistat.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Cobicistat.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Cobicistat.
Deflazacort Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Cobicistat.
Safinamide Safinamide The metabolism of Cobicistat can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Cobicistat can be decreased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Neratinib can be increased when it is combined with Cobicistat.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Cobicistat.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Cobicistat.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Cobicistat.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Cobicistat.
Delafloxacin Delafloxacin Cobicistat may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Cobicistat.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Cobicistat.
Acalabrutinib Acalabrutinib The metabolism of Cobicistat can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Cobicistat.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Cobicistat.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Cobicistat.
Buprenorphine Injection Buprenorphine Injection The serum concentration of Buprenorphine can be increased when it is combined with Cobicistat.
Apalutamide Apalutamide The metabolism of Cobicistat can be decreased when combined with Apalutamide.
Penicillamine Penicillamine The excretion of Penicillamine can be decreased when combined with Cobicistat.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Cobicistat.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Cobicistat.
Lofexidine Lofexidine The metabolism of Lofexidine can be decreased when combined with Cobicistat.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Cobicistat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Cobicistat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Cobicistat.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Cobicistat.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Cobicistat.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Cobicistat.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Cobicistat.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Cobicistat.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Cobicistat.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Cobicistat.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Cobicistat.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Cobicistat.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Cobicistat.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Cobicistat.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Cobicistat.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Cobicistat.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Cobicistat.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Cobicistat.
Rifamycin Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Cobicistat.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Cobicistat.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Cobicistat can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Cobicistat is combined with Siponimod.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Cobicistat.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Cobicistat.
Cladribine Cladribine Cobicistat may decrease the excretion rate of Cladribine which could result in a higher serum level.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The risk or severity of adverse effects can be increased when Cobicistat is combined with Polatuzumab vedotin.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Cobicistat.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Cobicistat.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Cobicistat.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Cobicistat.
Upadacitinib Upadacitinib The metabolism of Upadacitinib can be decreased when combined with Cobicistat.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Cobicistat.
Pitolisant Pitolisant The serum concentration of Cobicistat can be decreased when it is combined with Pitolisant.
Pretomanid Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Cobicistat.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Cobicistat.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Cobicistat.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Cobicistat.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Cobicistat.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Cobicistat.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Cobicistat.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Cobicistat.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Cobicistat.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Cobicistat.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Cobicistat.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Cobicistat.
Bempedoic Acid Bempedoic Acid The excretion of Bempedoic acid can be decreased when combined with Cobicistat.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Cobicistat.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Cobicistat.
Ozanimod Ozanimod Cobicistat may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Cobicistat.
Rimegepant Rimegepant The metabolism of Rimegepant can be decreased when combined with Cobicistat.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Cobicistat.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Cobicistat.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Cobicistat.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Cobicistat.
Capmatinib Capmatinib The serum concentration of Capmatinib can be increased when it is combined with Cobicistat.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Cobicistat.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Cobicistat.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Cobicistat.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Cobicistat.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Cobicistat can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Cobicistat.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The serum concentration of Drospirenone can be decreased when it is combined with Cobicistat.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Cobicistat.
Trazodone Trazodone The serum concentration of Trazodone can be increased when it is combined with Cobicistat.
Phenobarbital Phenobarbital The serum concentration of Cobicistat can be decreased when it is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Cobicistat.
Primidone Primidone The serum concentration of Cobicistat can be decreased when it is combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Cobicistat.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Cobicistat.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Cobicistat.
Codeine Codeine The metabolism of Codeine can be decreased when combined with Cobicistat.
Bromocriptine Bromocriptine The serum concentration of Bromocriptine can be increased when it is combined with Cobicistat.
Phenelzine Phenelzine The metabolism of Cobicistat can be decreased when combined with Phenelzine.
Ergoloid Mesylates Ergoloid Mesylates The serum concentration of Ergoloid mesylate can be increased when it is combined with Cobicistat.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Cobicistat.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Cobicistat.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Cobicistat.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Cobicistat.
Methadone Methadone The serum concentration of Methadone can be increased when it is combined with Cobicistat.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Cobicistat.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Cobicistat.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Cobicistat.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Cobicistat.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Cobicistat.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Cobicistat.
Sulfasalazine Sulfasalazine Cobicistat may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Cobicistat.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Cobicistat.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Cobicistat.
Carbamazepine Carbamazepine The metabolism of Cobicistat can be increased when combined with Carbamazepine.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Cobicistat.
Prazosin Prazosin Cobicistat may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Cobicistat can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Cobicistat.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Cobicistat.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Cobicistat.
Daunorubicin Daunorubicin Cobicistat may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Cobicistat may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Cobicistat may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Cobicistat.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Cobicistat.
Isosorbide Isosorbide The serum concentration of Isosorbide can be decreased when it is combined with Cobicistat.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Cobicistat.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Cobicistat.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Cobicistat.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Cobicistat.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Cobicistat.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Cobicistat.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Cobicistat.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Cobicistat.
Liothyronine Liothyronine The excretion of Liothyronine can be decreased when combined with Cobicistat.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Cobicistat.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cobicistat.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Cobicistat.
Meclizine Meclizine The metabolism of Meclizine can be decreased when combined with Cobicistat.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Cobicistat.
Folic Acid Folic Acid Cobicistat may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Cobicistat.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Cobicistat.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Cobicistat.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Cobicistat.
Allopurinol Allopurinol Cobicistat may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Cobicistat.
Fluorouracil Injection Fluorouracil Injection Cobicistat may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Cobicistat.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Cobicistat.
Ketoconazole Ketoconazole The serum concentration of Cobicistat can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Cobicistat.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Cobicistat.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Cobicistat.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Cobicistat.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be decreased when combined with Cobicistat.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Cobicistat.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Cobicistat.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Cobicistat.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Cobicistat.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Cobicistat.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Cobicistat.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Cobicistat.
Pindolol Pindolol The metabolism of Pindolol can be decreased when combined with Cobicistat.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Cobicistat.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Cobicistat.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Cobicistat.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Cobicistat.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Cobicistat.
Enalapril Enalapril The excretion of Enalapril can be decreased when combined with Cobicistat.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Cobicistat.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Cobicistat.
Lovastatin Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Cobicistat.
Ciprofloxacin Ciprofloxacin The metabolism of Cobicistat can be decreased when combined with Ciprofloxacin.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Cobicistat.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Cobicistat.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Cobicistat.
Clarithromycin Clarithromycin The metabolism of Cobicistat can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Cobicistat.
Pravastatin Pravastatin Cobicistat may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Cobicistat.
Amlodipine Amlodipine The metabolism of Amlodipine can be decreased when combined with Cobicistat.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Cobicistat.
Itraconazole Itraconazole The metabolism of Cobicistat can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The serum concentration of Rifabutin can be increased when it is combined with Cobicistat.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Cobicistat.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Cobicistat.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Cobicistat.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Cobicistat.
Cisapride Cisapride The risk or severity of QTc prolongation and Cardiac Arrhythmia can be increased when Cobicistat is combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Cobicistat.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Cobicistat.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Cobicistat.
Fluvoxamine Fluvoxamine The metabolism of Cobicistat can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Nefazodone can be decreased when combined with Cobicistat.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Cobicistat.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Cobicistat.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Cobicistat.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Cobicistat.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Cobicistat.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Cobicistat.
Lamivudine Lamivudine Cobicistat may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Cobicistat may decrease the excretion rate of Riluzole which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Cobicistat.
Indinavir Indinavir The metabolism of Indinavir can be decreased when combined with Cobicistat.
Ritonavir Ritonavir The serum concentration of Cobicistat can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Cobicistat.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Cobicistat.
Zafirlukast Zafirlukast The metabolism of Cobicistat can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Cobicistat.
Valsartan Valsartan The excretion of Valsartan can be decreased when combined with Cobicistat.
Donepezil Donepezil Cobicistat may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir The metabolism of Cobicistat can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Cobicistat.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Cobicistat.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Cobicistat.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Cobicistat.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Cobicistat.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Cobicistat.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Cobicistat.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Cobicistat.
Raloxifene Raloxifene Cobicistat may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Cobicistat.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Cobicistat.
Quetiapine Quetiapine The serum concentration of Quetiapine can be increased when it is combined with Cobicistat.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Cobicistat.
Citalopram Citalopram The metabolism of Citalopram can be decreased when combined with Cobicistat.
Efavirenz Efavirenz The metabolism of Cobicistat can be increased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Cobicistat.
Celecoxib Celecoxib Cobicistat may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Tolterodine Tolterodine The serum concentration of Tolterodine can be increased when it is combined with Cobicistat.
Thalidomide Thalidomide The metabolism of Cobicistat can be increased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Cobicistat.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Cobicistat.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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