Cobimetinib with Dronedarone Interaction Details
Brand Names Associated with Cobimetinib
- Cobimetinib
- Cotellic®
Brand Names Associated with Dronedarone
- Dronedarone
- Multaq®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 26, 2023
Interaction Effect
Increased cobimetinib plasma concentrations
Interaction Summary
Avoid concomitant use of cobimetinib (a CYP3A substrate) with moderate CYP3A inhibitors, as coadministration may result in increased cobimetinib plasma concentrations. If short-term (14 days or less) administration of moderate CYP3A inhibitors is necessary in patients taking cobimetinib 60 mg, reduce the cobimetinib dose to 20 mg. After discontinuing the moderate CYP3A inhibitor, resume cobimetinib at the previous dose. In patients already taking a reduced cobimetinib dose (ie, 40 or 20 mg/day), use an alternative to the CYP3A inhibitor.
Severity
Major
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
Avoid concomitant use of cobimetinib (a CYP3A substrate) with moderate CYP3A inhibitors, as coadministration may result in increased cobimetinib plasma concentrations. If short-term (14 days or less) administration of moderate CYP3A inhibitors is necessary in patients taking cobimetinib 60 mg, reduce the cobimetinib dose to 20 mg. After discontinuing the moderate CYP3A inhibitor, resume cobimetinib at the previous dose. In patients already taking a reduced cobimetinib dose (ie, 40 or 20 mg/day), use an alternative to the CYP3A inhibitor.
Mechanism Of Interaction
Inhibition of CYP3A4-mediated metabolism of cobimetinib
Literature Reports
A) Simulated concurrent use of cobimetinib at a reduced dose of 20 mg with short-term (less than 14 days) treatment of a moderate CYP3A inhibitor showed that predicted cobimetinib steady-state concentrations were similar to observed steady-state concentrations of cobimetinib 60 mg alone .
Cobimetinib Overview
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Cobimetinib is used along with vemurafenib (Zelboraf) to treat certain types of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Cobimetinib is also used to treat histiocytic neoplasms (conditions that cause an overproduction and accumulation of a type of white blood cell in parts of the body). Cobimetinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.
Dronedarone Overview
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Dronedarone is used to treat people who currently have normal heart rhythm, but have had atrial fibrillation in the past. Dronedarone decreases the risk that people who have this condition will need to be hospitalized to treat atrial fibrillation. Dronedarone is in a class of medications called antiarrhythmics. It works by helping the heart to beat normally.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.