Digoxin with Propantheline Interaction Details
Brand Names Associated with Digoxin
- Cardoxin®
- Digitek®
- Digoxin
- Lanoxicaps®
- Lanoxin®
Brand Names Associated with Propantheline
- Pro-Banthine®
- Propantheline
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jan 08, 2024
Interaction Effect
Increased serum digoxin levels
Interaction Summary
Propantheline inhibits gastrointestinal motility. When used concurrently with a slow-dissolving digoxin preparation, increased absorption and serum digoxin levels may result. This interaction can be avoided by using digoxin formulations that dissolve rapidly according to USP standards .
Severity
Major
Onset
Rapid
Evidence
Probable
How To Manage Interaction
Monitor digoxin serum levels when propantheline and a slow-dissolving digoxin preparation are used concurrently. Adjust the digoxin dose if necessary. This interaction can be avoided by using digoxin formulations that dissolve rapidly according to USP standards.
Mechanism Of Interaction
Increased absorption due to decreased gastrointestinal motility
Literature Reports
A) Serum digoxin levels with or without propantheline were studied in 13 elderly women on maintenance digoxin therapy. Propantheline 15 mg three times daily orally was administered for 10 days, resulting in an increase in serum digoxin concentrations from initial levels of 1.02 nanogram/mL (ng/mL; 1.306 nanomol/L) to 1.33 ng/mL (1.703 nanomol/L). A second group of volunteers, comprised of healthy medical students, was administered either digoxin 0.5 mg in tablet form or digoxin 0.5 mg in liquid form 30 minutes after administration of propantheline 30 mg. Administration of propantheline increased serum digoxin concentrations in the four subjects who received digoxin tablets but not in the 4 subjects who received digoxin liquid .
B) In a randomized, crossover study, the effect of propantheline on the absorption of various particle-size digoxin preparations was evaluated. Ten healthy volunteers each received single doses of standardized digoxin (Lanoxin(R) brand) 0.5 mg, micronized digoxin 0.5 mg, or large particle-size digoxin 0.5 mg. Each subject also received either propantheline 30 mg, metoclopramide 10 mg, or placebo with each digoxin dose, for a total of 9 treatment combinations, separated by at least 2 weeks. Neither standardized nor micronized digoxin preparations were affected by the coadministration of propantheline. However, absorption of the large particle-size preparation was increased by concomitant administration of propantheline compared with placebo .
Digoxin Overview
-
Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.
Propantheline Overview
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Propantheline is used with other medication to treat ulcers. Propantheline is in a class of medications called anticholinergics. It works by slowing the movement of food through the stomach and intestines and decreasing the amount of acid made by the stomach.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.