Doxycycline with Magnesium Trisilicate Interaction Details


Brand Names Associated with Doxycycline

  • Acticlate CAP®
  • Acticlate®
  • Doryx MPC®
  • Doryx®
  • Doxychel®
  • Doxycycline
  • Monodox®
  • Oracea®
  • Periostat®
  • Vibra-Tabs®
  • Vibramycin®

Medical Content Editor
Last updated Nov 13, 2023


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Interaction Effect

Decreased effectiveness of tetracyclines


Interaction Summary

Aluminum, calcium or magnesium containing products may impair the absorption of orally administered tetracyclines (up to 90%). If the patient is taking both medications, space them at least 1 to 2 hours apart.


Severity

Moderate


Onset

Rapid


Evidence

Probable


How To Manage Interaction

Concurrent administration of any of the tetracyclines and aluminum, calcium or magnesium containing products is not recommended. If concurrent use cannot be avoided, tetracyclines should be taken at least one to two hours before aluminum, calcium or magnesium containing products. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antibiotic efficacy.


Mechanism Of Interaction

Decreased absorption and half-life of tetracyclines


Literature Reports

A) Antacids may significantly enhance the total body clearance and renal clearance of intravenous doxycycline and may reduce oral bioavailability .

B) Antacids containing divalent or trivalent cations (calcium, magnesium, aluminum) impair the absorption of oral tetracyclines and result in decreased serum levels . Milk and milk products reportedly affect oral doxycycline absorption to a lesser degree than tetracycline .

C) Combined therapy with oral antacids (aluminum hydroxide gel) and intravenous doxycycline resulted in a significant increase in the total clearance and renal clearance of doxycycline for six healthy volunteers. The subjects were given intravenous doxycycline 200 mg on two occasions, separated by a 7-day washout period; on one occasion, oral aluminum hydroxide gel was given concomitantly beginning 48 hours prior to the doxycycline and continuing for a total of 16 doses as 30 mL four times daily. When given concomitantly with antacids, the half-life of doxycycline decreased from 16.2 to 11.2 hours and the total body clearance increased from 37.4 to 54.1 mL/min. In addition, the area under the plasma concentration-time curve (AUC) decreased significantly with an increase in renal clearance .

Doxycycline Overview

  • Doxycycline is used to treat a variety of infections caused by certain types of bacteria. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria. Doxycycline is also used along with other medications to treat acne and rosacea (a skin disease that causes redness, flushing, and pimples on the face). Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea. Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition.

  • Antibiotics such as doxycycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See More information Regarding Doxycycline

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Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.


Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.


Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.


How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.


Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.


Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.