Duloxetine with Fluvoxamine Interaction Details
Brand Names Associated with Duloxetine
- Cymbalta®
- Drizalma Sprinkle®
- Duloxetine
Brand Names Associated with Fluvoxamine
- Fluvoxamine
- Luvox®
- Luvox® CR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 11, 2023
Interaction Effect
Increased DULoxetine exposure and an increased risk of serotonin syndrome
Interaction Summary
Coadministration of DULoxetine together with fluvoxaMINE should be avoided. DULoxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) that is primarily metabolized by the CYP1A2 and CYP2D6 isozymes. The concomitant use of DULoxetine with fluvoxaMINE, a SSRI, is not recommended due to the potential for serotonin syndrome. In addition, coadministration of fluvoxaMINE 100 mg (a CYP1A2 inhibitor) with DULoxetine 40 mg twice a day in 14 CYP2D6 poor metabolizer subjects resulted in a 6-fold increase in DULoxetine AUC and Cmax. Also, when 14 male patients were given DULoxetine 60 mg together with fluvoxaMINE 100 mg, DULoxetine AUC, Cmax, and half-life increased by 6-fold, about 2.5-fold, and 3-fold, respectively .
Severity
Major
Onset
Unspecified
Evidence
Established
How To Manage Interaction
The concomitant use of DULoxetine and fluvoxaMINE is not recommended due to the potential for development of serotonin syndrome. Additionally, concomitant use of DULoxetine with fluvoxaMINE (a strong CYP1A2 inhibitor) has resulted in increased AUC and Cmax of DULoxetine (especially in poor CYP2D6 metabolizers) in a study. Coadministration should therefore be avoided .
Mechanism Of Interaction
Inhibition of CYP1A2-mediated DULoxetine metabolism; inhibition of CYP2D6-mediated metabolism of duloxetine; additive serotonergic effects
Literature Reports
A) When DULoxetine 60 mg was coadministered with fluvoxaMINE 100 mg (a strong CYP1A2 inhibitor) to male subjects (n=14) DULoxetine AUC was increased approximately 6-fold, the Cmax was increased about 2.5-fold, and DULoxetine t(1/2) was increased approximately 3-fold .
B) Concomitant use of DULoxetine 40 mg twice daily with fluvoxaMINE 100 mg (a strong CYP1A2 inhibitor) in known CYP2D6 poor metabolizers (n=14) resulted in a 6-fold increase in DULoxetine AUC and Cmax .
Duloxetine Overview
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Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) in adults and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep) in adults and children 13 years of age and older. It is also used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis (joint pain or stiffness that may worsen over time) in adults. Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
Fluvoxamine Overview
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Fluvoxamine is used to treat obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over) and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). Fluvoxamine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.