Fedratinib with Metformin Interaction Details

Brand Names Associated with Metformin

  • Actoplus Met® (as a combination product containing Metformin, Pioglitazone)
  • Avandamet® (as a combination product containing Metformin, Rosiglitazone)
  • Fortamet®
  • Glucophage®
  • Glumetza®
  • Invokamet® (as a combination product containing Canagliflozin, Metformin)
  • Janumet® (as a combination product containing Metformin, Sitagliptin)
  • Jentadueto® (as a combination product containing Linagliptin, Metformin)
  • Kazano® (as a combination product containing Alogliptin, Metformin)
  • Kombiglyze® XR (as a combination product containing Metformin, Saxagliptin)
  • Metaglip® (as a combination product containing Glipizide, Metformin)
  • Metformin
  • Prandimet® (as a combination product containing Metformin, Repaglinide)
  • Qternmet® XR (as a combination product containing Dapagliflozin, Metformin, Saxagliptin), Segluromet® (as a combination product containing Ertugliflozin, Metformin)
  • Riomet®
  • Synjardy® (as a combination product containing Empagliflozin, Metformin)
  • Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
  • Xigduo® XR (as a combination product containing Dapagliflozin, Metformin)

Medical Content Editor
Last updated Dec 27, 2023

Curious for more information about this interaction?

Ask our pharmacists directly!

Reach out to us

Interaction Effect

Increased metFORMIN exposure and an increased risk of metFORMIN-related adverse events

Interaction Summary

Coadministration of fedratinib with drugs that are renally excreted by organic cation transporter (OCT2) and multidrug and toxin extrusion (MATE)1/2-K such as metFORMIN can decrease the renal clearance of metFORMIN. In a pharmacokinetic study, single-dose coadministration of fedratinib with metformin (OCT2 and MATE1/2-K substrate) did not significantly change metformin AUC but did reduce renal clearance of metformin by 36%. If coadministration is necessary, monitor for adverse reactions and consider dose modifications for drugs renally excreted by OCT2 or MATE1/2-K.

Severity

Major

Onset

Unspecified

Evidence

Probable

How To Manage Interaction

Coadministration of fedratinib with drugs that are renally excreted by organic cation transporter (OCT2) and multidrug and toxin extrusion (MATE)1/2-K such as metFORMIN can decrease the renal clearance of metFORMIN. If coadministration is necessary, monitor for adverse reactions and consider dose modifications for drugs renally excreted by OCT2 or MATE1/2-K.

Mechanism Of Interaction

Reduced renal clearance of metFORMIN; inhibition of OCT2 or MATE1/2-K efflux transport of metFORMIN by fedratinib

Literature Reports

A) Single-dose coadministration of fedratinib 600 mg and metformin 1000 mg (OCT2 and MATE1/2-K substrate) reduced the renal clearance of metformin by 36% .

Metformin Overview

  • Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See More information Regarding Metformin

Return To Our Drug Interaction Homepage

Feedback, Question Or Comment About This Information?

Ask , our medical editor, directly! He's always more than happy to assist.

Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.

Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.

How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.

Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.