Furosemide with Cephaloridine Interaction Details
Brand Names Associated with Furosemide
- Furosemide
- Lasix®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 10, 2023
Interaction Effect
An increased risk of cephaloridine toxicity
Interaction Summary
The concurrent administration of furosemide and cephaloridine has been shown to increase the plasma concentrations and half-life of cephaloridine, thereby increasing the risk of cephaloridine toxicity. Nephrotoxicity, reversible encephalopathy, and acute renal failure have been reported during high-dose therapy with cephaloridine , and the concomitant use of furosemide may increase the risk of developing cephaloridine toxicity. Animal studies have revealed a higher incidence and greater extent of renal tubular necrosis in subjects that received both furosemide and cephaloridine .
Severity
Moderate
Onset
Delayed
Evidence
Established
How To Manage Interaction
Monitor renal function in patients with pre-existing renal disease who are receiving concurrent furosemide and cephaloridine. Even in the presence of normal renal function, it has been suggested that the dose of cephaloridine should not exceed 4 grams daily.
Mechanism Of Interaction
Depression of the glomerular filtration rate and competition for tubular secretion
Literature Reports
A) The concurrent administration of furosemide and cephaloridine resulted in a decrease in the renal clearance and a corresponding increase in the plasma concentrations of cephaloridine . Intravenous furosemide 20 mg was given to four healthy subjects concomitantly with intravenous cephaloridine 250 mg. Measurements of the renal clearance of cephaloridine showed that it decreased from an average of 213 mL/min in the control study to 136 mL/min when administered with furosemide. Cephaloridine plasma levels increased from an average of 4.4 mcg/mL in the control study to 8.5 mcg/mL when given with furosemide. Possible mechanisms for this drug interaction include competition for tubular secretion between furosemide and cephaloridine, in addition to depression of glomerular filtrate rate.
B) The effect of an 80 mg oral dose of furosemide on the serum half-life of cephaloridine was evaluated in 14 hospitalized patients. Doses of cephaloridine were either 1 gram or 0.5 grams intramuscularly three times daily, depending on the age of the patient. At no time did the peak serum concentration of cephaloridine exceed 61.5 mcg/mL, and the trough concentrations were always below 8.0 mcg/mL. The mean serum half-life of cephaloridine increased from 2.0 hours before furosemide to 2.5 hours during concurrent therapy with furosemide, an increase of 25%. Cephaloridine half-life again returned to prior values after the discontinuation of furosemide. Renal function was not affected in this study by the concomitant administration of cephaloridine and furosemide .
Furosemide Overview
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Furosemide is used alone or in combination with other medications to treat high blood pressure. Furosemide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease. Furosemide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
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High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.