Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Contraindicated

Hydrocortisone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details Hydrocortisone Desmopressin DDAVP Increased risk of severe hyponatremia Details Hydrocortisone Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Hydrocortisone Mifepristone Korlym Increased CYP3A4 substrate exposure and an increased risk of autoimmune disorders and acute adrenal insufficiency, that may lead t... Details

Major

Hydrocortisone Abametapir Increased exposure of CYP3A4 substrate Details Hydrocortisone Aldesleukin Proleukin Reduced antitumor effectiveness Details Hydrocortisone Aspirin Acuprin® An increased risk of gastrointestinal adverse reactions; increased aspirin exposure and an increased risk of salicylism subsequent... Details Hydrocortisone Aspirin Rectal Aspirin An increased risk of gastrointestinal adverse reactions; increased aspirin exposure and an increased risk of salicylism subsequent... Details Hydrocortisone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Hydrocortisone Bromfenac Ophthalmic Bromday® Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Cyclosporine Injection Atopica Increased hydrocortisone exposure, an increased cycloSPORINE exposure and an increased risk of convulsions Details Hydrocortisone Cyclosporine Ophthalmic Cequa Increased hydrocortisone exposure, an increased cycloSPORINE exposure and an increased risk of convulsions Details Hydrocortisone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Estradiol Delestrogen Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Hydrocortisone Estradiol Topical Divigel Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Hydrocortisone Estradiol Transdermal Patch Alora® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Hydrocortisone Etodolac Lodine Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Fenoprofen Fenopron Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Flurbiprofen Ansaid Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Flurbiprofen Ophthalmic Ocufen Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Hydrocortisone Gemifloxacin Factive An increased risk of tendon rupture Details Hydrocortisone Aceclofenac Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Acemetacin Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Amtolmetin Guacil Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Hydrocortisone Atazanavir Reyataz Increased corticosteroid exposure and an increased risk of corticosteroid-related adverse effects Details Hydrocortisone Avacopan Tavneos Increased CYP3A4 substrate exposure Details Hydrocortisone Balofloxacin An increased risk of tendon rupture Details Hydrocortisone Balsalazide Disodium An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Hydrocortisone Bemiparin Increased risk of bleeding Details Hydrocortisone Besifloxacin An increased risk of tendon rupture Details Hydrocortisone Bromfenac Bromsite Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Bufexamac Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Bupropion Aplenzin Lowering of the seizure threshold Details Hydrocortisone Carbamazepine Carbatrol Reduced hydrocortisone exposure and reduced efficacy of hydrocortisone Details Hydrocortisone Celecoxib Celebrex Increased risk of gastrointestinal ulcer or bleeding Details

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