Ivosidenib Interactions
Ivosidenib is used to treat a certain type of acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells) that has returned or that has not improved after previous treatment(s). Ivosidenib is also used alone or in combination with azacitidine (Onureg) to treat a certain type of AML in some adults older than 75 years of age as a first treatment. Ivosidenib is also used in adults who have already received previous treatment(s) to treat a certain type of cholangiocarcinoma (bile duct cancer) that has spread to nearby tissues or other parts of the body. Ivosidenib is in a class of medications called IDH1 inhibitors. It works by slowing or stopping the growth of cancer cells.
Brand Names Associated with Ivosidenib
- Ivosidenib
- Tibsovo®
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- Contraindicated
- Major
- Imatinib
- Warfarin
- Azithromycin
- Sertraline
- Quetiapine
- Risperidone
- Clarithromycin
- Ticagrelor
- Simvastatin
- Escitalopram
- Trazodone
- Fluoxetine
- Citalopram
- Fluticasone Propionate
- Cyclobenzaprine
- Venlafaxine
- Ethinyl Estradiol; Norethindrone
- Sildenafil
- Zolpidem
- Buspirone
- Estradiol
- Famotidine
- Hydroxyzine
- Diltiazem
- Amitriptyline
- Paroxetine
- Ondansetron
- Celecoxib
- Lovastatin
- Mirtazapine
- Donepezil
- Hydroxychloroquine
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- Deutetrabenazine
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- Ceritinib
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- Osimertinib
- Tamoxifen
- Nilotinib
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- Adagrasib
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- Amisulpride
- Anagrelide
- Apomorphine
- Aprepitant
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Asciminib
- Asenapine
- Astemizole
- Atazanavir
- Avacopan
- Avanafil
- Bedaquiline
- Boceprevir
- Budesonide
- Buserelin
- Capivasertib
- Chloroquine
- Chlorpromazine
- Clofazimine
- Clomipramine
- Clothiapine
- Clozapine
- Cobicistat
- Cobimetinib
- Conivaptan
- Crizotinib
- Cyclosporine
- Daridorexant
- Darifenacin
- Darunavir
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Desogestrel
- Dexmedetomidine
- Dienogest
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Doxepin
- Droperidol
- Drospirenone
- Ebastine
- Efavirenz
- Eletriptan
- Elexacaftor
- Encorafenib
- Entrectinib
- Enzalutamide
- Eplerenone
- Eribulin
- Erythromycin
- Estetrol
- Ethinyl Estradiol
- Ethynodiol
- Etonogestrel
- Etrasimod
- Fedratinib
- Felbamate
- Felodipine
- Fexinidazole
- Fingolimod
- Fluticasone
- Fluvoxamine
- Formoterol
- Fosaprepitant
- Foscarnet
- Fosnetupitant
- Fosphenytoin
- Fostemsavir
- Fruquintinib
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Gepirone
- Gestodene
- Glasdegib
- Gonadorelin
- Goserelin
- Granisetron
- Halofantrine
- Haloperidol
- Histrelin
- Hydroquinidine
- Ibrexafungerp
- Ibrutinib
- Ibutilide
- Iloperidone
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Itraconazole
- Ivabradine
- Ivacaftor
- Lanreotide
- Lapatinib
- Lefamulin
- Lenvatinib
- Letermovir
- Leuprolide
- Levofloxacin
- Levonorgestrel
- Lofexidine
- Lomitapide
- Lopinavir
- Lumacaftor
- Lumefantrine
- Lurasidone
- Lurbinectedin
- Macimorelin
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Mestranol
- Methadone
- Methotrimeprazine
- Metronidazole
- Midazolam
- Mifepristone
- Mitotane
- Mizolastine
- Mobocertinib
- Moricizine
- Moxifloxacin
- Nafarelin
- Naloxegol
- Nefazodone
- Nelfinavir
- Netupitant
- Nirmatrelvir
- Nomegestrol
- Norelgestromin
- Norethindrone
- Norfloxacin
- Norgestimate
- Norgestrel
- Octreotide
- Ofloxacin
- Omaveloxolone
- Osilodrostat
- Oxaliplatin
- Ozanimod
- Pacritinib
- Paliperidone
- Palovarotene
- Panobinostat
- Papaverine
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pipamperone
- Pitolisant
- Ponesimod
- Pralsetinib
- Primidone
- Probucol
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quinidine
- Quinine
- Quizartinib
- Ranolazine
- Relugolix
- Ribociclib
- Rifampin
- Ritlecitinib
- Ritonavir
- Segesterone
- Selpercatinib
- Sertindole
- Sevoflurane
- Siponimod
- Sirolimus
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- St John's Wort
- Sulpiride
- Sultopride
- Sunitinib
- Tacrolimus
- Telaprevir
- Telavancin
- Telithromycin
- Temsirolimus
- Tetrabenazine
- Tezacaftor
- Tipranavir
- Tocilizumab
- Tolterodine
- Tolvaptan
- Toremifene
- Triazolam
- Triclabendazole
- Trimipramine
- Triptorelin
- Ulipristal
- Valbenazine
- Vandetanib
- Vardenafil
- Vemurafenib
- Venetoclax
- Vilanterol
- Vilazodone
- Vinflunine
- Voclosporin
- Vonoprazan
- Voriconazole
- Vorinostat
- Vortioxetine
- Zotepine
- Zuclopenthixol
- Zuranolone
- Moderate
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What Do The Severity Ratings Mean?
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Drug interaction information is compilated from several drug compendia, including:
- Gold Standard Drug Database
- Micromedix
- Lexicomp
- PubMed
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.