Ketoconazole with Solifenacin Interaction Details
Brand Names Associated with Ketoconazole
- Ketoconazole
- Nizoral®
Brand Names Associated with Solifenacin
- Solifenacin
- VESIcare LS®
- VESIcare®
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 02, 2023
Interaction Effect
Increased plasma concentration of solifenacin and increased risk of QT-interval prolongation
Interaction Summary
Using ketoconazole together with a CYP3A4 substrate known to prolong the QT interval, such as solifenacin may be contraindicated. Concomitant use may result in elevated plasma concentrations of solifenacin, increasing the risk for QT prolongation and life-threatening ventricular tachyarrhythmias, including torsades de pointes. Administration of 10 mg of solifenacin in the presence of 400 mg ketoconazole resulted in a 1.5- and 2.7-fold increase of the mean Cmax and AUC of solifenacin, respectively. The mechanism of action is thought to be ketoconazole inhibition of CYP3A4-mediated metabolism of solifenacin. A dose-dependent effect on the QT interval was observed with a 30-mg dose of solifenacin (equivalent to the exposure achieved when 10 mg of solifenacin is coadministered with a potent CYP3A4 inhibitor, such as ketoconazole 400 mg). If concomitant use is required, do not exceed 5 mg solifenacin once daily when used concomitantly with a potent CYP3A4 inhibitor such as ketoconazole . Ketoconazole is also associated independently with QT interval prolongation . Consider monitoring baseline and on-treatment ECG for QT interval prolongation.
Severity
Contraindicated
Onset
Unspecified
Evidence
Probable
How To Manage Interaction
Using ketoconazole together with a CYP3A4 substrate known to prolong the QT interval, such as solifenacin may be contraindicated. Concomitant use may result in elevated plasma concentrations of solifenacin, increasing the risk for QT prolongation and life-threatening ventricular tachyarrhythmias, including torsades de pointes. Additionally, QT interval prolongation has also been associated with ketoconazole use and additive effects on the QT interval may occur with concomitant use If concomitant use is required, a dose limit of solifenacin 5 mg daily is recommended when concomitantly used with potent CYP3A4 inhibitors such as ketoconazole . Consider monitoring baseline and on-treatment ECG for QT interval prolongation.
Mechanism Of Interaction
Inhibition of CYP3A4-mediated metabolism of solifenacin; additive QT-interval prolongation
Ketoconazole Overview
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Ketoconazole is used to treat fungal infections when other medications are not available or cannot be tolerated. Ketoconazole should not be used to treat fungal meningitis (infection of the membranes surrounding the brain and spinal cord caused by a fungus) or fungal nail infections. Ketoconazole is in a class of antifungals called imidazoles. It works by slowing the growth of fungi that cause infection.
Solifenacin Overview
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Solifenacin (VESIcare) is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination). Solifenacin (VESIcare LS) is used to treat neurogenic detrusor overactivity (a bladder control condition caused by brain, spinal cord or nerve problem) in children 2 years of age and older. Solifenacin is in a class of medications called antimuscarinics. It works by relaxing the bladder muscles.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.