Losartan

Contraindicated

Losartan Aliskiren Tekturna An increased risk of hyperkalemia, renal impairment, and hypotension Details Losartan Sparsentan Filspari An increased risk of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure), reduced CY... Details

Major

Losartan Lisinopril Prinivil Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Benazepril Lotensin Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Losartan Captopril Capoten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Cyclosporine Injection Atopica An increased risk of hyperkalemia Details Losartan Cyclosporine Ophthalmic Cequa An increased risk of hyperkalemia Details Losartan Digoxin Cardoxin® An increased digoxin exposure Details Losartan Enalapril Epaned Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Entacapone Comtan Increased exposure of CYP2C9 substrate Details Losartan Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Losartan Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Losartan Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Losartan Fosinopril Monopril® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Furosemide Injection Disal Severe hypotension and deterioration in renal function, including renal failure Details Losartan Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Losartan Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Losartan Carbamazepine Carbatrol Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Losartan Ceritinib Zykadia Increased exposure of CYP3A and CYP2C9 substrate Details Losartan Cilazapril Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Cyclosporine Atopica An increased risk of hyperkalemia Details Losartan Deutivacaftor Increased CYP2C9 substrate exposure Details Losartan Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Losartan Enalaprilat Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Furosemide Disal Severe hypotension and deterioration in renal function, including renal failure Details Losartan Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Losartan Lithium Increased risk of lithium toxicity Details Losartan Moexipril Univasc® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Perindopril Aceon Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Phenobarbital Fidoquel Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Losartan Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Losartan Potassium Phosphate K-Phos Increased risk of severe and potentially fatal hyperkalemia Details Losartan Primidone Mysoline Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Losartan Quinapril Accupril Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Ramipril Altace Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Rifampin Rifadin Reduced losartan exposure and reduced losartan active metabolite exposure Details Losartan Sacubitril Increased risk of adverse events Details Losartan Spirapril Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Losartan Spironolactone Aldactone An increased risk of hyperkalemia, an increased risk of hypotension and an increased risk of worsening of renal function Details