Maraviroc and Etravirine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Etravirine
Maraviroc
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased maraviroc plasma concentrations and exposure (AUC)
Interaction Deep Dive
When maraviroc and etravirine were coadministered, the maraviroc AUC decreased 53%. The concomitant use of maraviroc (a CYP3A substrate) with etravirine (a CYP3A inducer) is contraindicated in adult and pediatric patients with CrCl less than 30 mL/min and in those with ESRD on regular hemodialysis. In adults with CrCl 30 mL/min or greater treated with maraviroc and etravirine (and no strong CYP3A inhibitors), increase the maraviroc dose to 600 mg orally twice daily. In pediatric patients with CrCl 30 mL/min or greater, concomitant use of maraviroc and etravirine is not recommended1.
Why it happens (mechanism)
Induction of CYP3A4-mediated maraviroc metabolism
Literature reports
1 report — tap to read
a) Concomitant administration of etravirine and maraviroc resulted in decreased maraviroc AUC and plasma concentrations. When etravirine 600 mg once daily was administered concurrently with maraviroc in 14 subjects, the maraviroc AUC and Cmax values were 53% and 60% lower, respectively 2.
Common questions
Can I take Maraviroc and Etravirine together?
Decreased maraviroc plasma concentrations and exposure (AUC) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Maraviroc and Etravirine interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Maraviroc or Etravirine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
Keep reading about Etravirine
Keep reading about Maraviroc
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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