Pacritinib with Indinavir Interaction Details
Brand Names Associated with Pacritinib
- Pacritinib
- Vonjo®
Brand Names Associated with Indinavir
- Crixivan®
- IDV
- Indinavir
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Dec 20, 2023
Interaction Effect
Increased pacritinib exposure and increased risk of adverse reactions
Interaction Summary
The coadministration of pacritinib with a strong CYP3A4 inhibitor is contraindicated because a significant increase in pacritinib exposure and risk for severe adverse effects may result. The addition of a single dose of pacritinib 400 mg to a submaximal dosage of a strong CYP3A4 inhibitor (clarithromycin 500 mg twice daily for 5 days) resulted in an increase in pacritinib AUC by 80% and Cmax by 30%; therefore, concurrent use of pacritinib with an optimally dosed strong CYP3A4 inhibitor could result in even higher pacritinib exposure.
Severity
Contraindicated
Onset
Unspecified
Evidence
Theoretical
How To Manage Interaction
The coadministration of pacritinib with a strong CYP3A4 inhibitor is contraindicated.
Mechanism Of Interaction
Inhibition of CYP3A4-mediated metabolism of pacritinib
Literature Reports
A) In a pharmacokinetic study, the addition of a single pacritinib dose of 400 mg to clarithromycin 500 mg twice daily for 5 days resulted in an increase in pacritinib AUC by 80% and Cmax by 30%. Concurrent ongoing use and a clinically used clarithromycin regimen may result in further increases in pacritinib exposure .
Pacritinib Overview
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Pacritinib is used to treat adults with certain types of myelofibrosis (MF; a cancer of the bone marrow in which the bone marrow is replaced by scar tissue and causes decreased blood cell production). Pacritinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
Indinavir Overview
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Indinavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Indinavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although indinavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people.
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Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.