Paroxetine

141 interactions 8 explained in plain English
Also sold as: Paxil
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Paroxetine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus, an increased risk of serotonin syndrome, an increased codeine exposure and reduced active metab... Details Paroxetine Amitriptyline Elavil Explained Increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased CYP2D6 substrate exposure Details Paroxetine Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Paroxetine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Paroxetine Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Paroxetine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Paroxetine Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Paroxetine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Paroxetine Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Paroxetine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Paroxetine Asenapine Transdermal Patch Secuado Increased PARoxetine exposure, an increased asenapine exposure and an increased risk of QT interval prolongation Details Paroxetine Aspirin Acuprin® An increased risk of bleeding Details Paroxetine Aspirin Rectal Aspirin An increased risk of bleeding Details Paroxetine Azathioprine Azasan An increased risk of hepatotoxicity Details Paroxetine Azithromycin AzaSite An increased risk of QT interval prolongation Details Paroxetine Betrixaban Bevyxxa® An increased risk of bleeding Details Paroxetine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Paroxetine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Paroxetine Anagrelide Agrylin Increased risk of QT interval prolongation and an increased risk of bleeding Details Paroxetine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Paroxetine Brexpiprazole Rexulti Increased brexpiprazole exposure Details Paroxetine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Paroxetine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paroxetine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paroxetine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Paroxetine Clopidogrel Plavix An increased risk of bleeding Details Paroxetine Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Paroxetine Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Paroxetine Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Paroxetine Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Paroxetine Dalteparin Injection Fragmin An increased risk of bleeding Details Paroxetine Dasatinib Phyrago An increased risk of QT interval prolongation Details Paroxetine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Paroxetine Deutetrabenazine Austedo Increased deutetrabenazine exposure; prolongation of QT interval Details Paroxetine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Paroxetine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Paroxetine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Paroxetine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.