Risperidone

61 interactions 5 explained in plain English

Also sold as: Perseris Risperdal Risperdal® M-TAB® Orally Disintegrating Tablets Risperdal® Oral Solution Risperdal® Tablets Rykindo Uzedy

About Risperidone

Risperidone is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and behavior problems in autism. Read the full Risperidone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Oxaliplatin Injection Lenvatinib Goserelin Implant Dofetilide

2 Contraindicated 58 Major 1 Moderate

All (61) Contraindicated (2) Major (58) Moderate (1)

Contraindicated

Risperidone Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Risperidone Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Risperidone Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Risperidone Sertraline Explained Increased risperiDONE exposure and an increased risk of QT interval prolongation Details Risperidone Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Risperidone Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Risperidone Simvastatin Flolipid Explained Increased simvastatin serum concentrations with an increased risk of myopathy or rhabdomyolysis Details Risperidone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Risperidone Arsenic Trioxide Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Risperidone Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Risperidone Arsenic Trioxide Injection Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Risperidone Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Risperidone Azithromycin AzaSite An increased risk of QT interval prolongation Details Risperidone Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Risperidone Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Risperidone Anagrelide Agrylin Increased risk of QT interval prolongation Details Risperidone Bedaquiline Sirturo Increased risk of QT interval prolongation Details Risperidone Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Risperidone Dasatinib Phyrago An increased risk of QT interval prolongation Details Risperidone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Risperidone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Risperidone Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Risperidone Dofetilide Tikosyn Increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Risperidone Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Risperidone Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Risperidone Encorafenib Braftovi Increased risk of QT interval prolongation Details Risperidone Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Risperidone Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Risperidone Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Risperidone Fostemsavir Rukobia Increased risk of torsade de pointes Details Risperidone Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Risperidone Glasdegib Daurismo Increased risk of QT interval prolongation Details Risperidone Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Risperidone Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Risperidone Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Risperidone Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Risperidone Ivabradine Corlanor Increased risk of QT prolongation Details Risperidone Ketoconazole Topical Extina® Foam Increased risperiDONE exposure and an increased risk of QT interval prolongation Details Risperidone Lefamulin Xenleta Increased risk of QT interval prolongation Details Risperidone Lenvatinib Lenvima Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.