Risperidone with Disopyramide Interaction Details
Brand Names Associated with Risperidone
- Risperdal® M-TAB® Orally Disintegrating Tablets
- Risperdal® Oral Solution
- Risperdal® Tablets
- Risperidone
Brand Names Associated with Disopyramide
- Disopyramide
- Norpace®
- Norpace® CR
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Nov 08, 2023
Interaction Effect
An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest)
Interaction Summary
Several antipsychotic agents have demonstrated QT prolongation including haloperidol, iloperidone, paliperidone, risperidone, sertindole, sultopride, and zotepine. Because Class IA antiarrhythmic agents may also prolong the QT interval and increase the risk of arrhythmias, the concurrent administration of antipsychotics with a drug from this class is not recommended .
Severity
Major
Onset
Unspecified
Evidence
Probable
How To Manage Interaction
The concurrent administration of a Class IA antiarrhythmic and an antipsychotic is not recommended.
Mechanism Of Interaction
Additive cardiac effects
Literature Reports
A) In an open-label QTc study of patients with schizophrenia or schizoaffective disorder (n=160), iloperidone 12 mg twice a day was associated with QTc prolongation of 9 msec .
B) QRS widening, QTc interval prolongation, and torsades de pointes may occur with disopyramide therapy .
C) The effects of combined therapy with quinidine (Class IA antiarrhythmic agent) and haloperidol (antipsychotic agent) were studied by giving 12 healthy volunteers haloperidol 5 mg alone and with 250 mg of quinidine bisulfate. The study demonstrated significant increases in the plasma concentrations of haloperidol when given concurrently with quinidine versus haloperidol treatment alone. The mean area under the concentration curve (AUC) was increased from 54.3 ng/hr/mL on haloperidol alone to 103.2 ng/hr/mL on combined therapy. The Cmax also showed an increase from 1.9 ng/mL on haloperidol to 3.8 ng/mL on combined therapy. Half-life (T1/2) and Tmax were not significantly changed, thereby suggesting to the authors that a tissue binding mechanism is more likely responsible for the plasma level changes than an elimination alteration .
Risperidone Overview
-
Risperidone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in adults and teenagers 13 years of age and older. It is also used to treat episodes of mania (frenzied, abnormally excited, or irritated mood) or mixed episodes (symptoms of mania and depression that happen together) in adults and in teenagers and children 10 years of age and older with bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Risperidone is also used to treat behavior problems such as aggression, self-injury, and sudden mood changes in teenagers and children 5 to 16 years of age who have autism (a condition that causes repetitive behavior, difficulty interacting with others, and problems with communication). Risperidone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Disopyramide Overview
-
Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity.
Return To Our Drug Interaction Homepage
Feedback, Question Or Comment About This Information?
Ask Dr. Brian Staiger, PharmD, our medical editor, directly! He's always more than happy to assist.
Definitions
Severity Categories
Contraindicated
These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.
Major
This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.
Moderate
This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.
Minor
While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
Onset
Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.
Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.
Evidence
Level of documentation of the interaction.
Established: The interaction is documented and substantiated in peer-reviewed medical literature.
Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.
How To Manage The Interaction
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.
It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.
Mechanism Of Interaction
The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.
Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.
Where Does Our Information Come From?
Information for our drug interactions is compiled from several drug compendia, including:
The prescribing information for each drug, as published on DailyMED, is also used.
Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.
The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.