Ticagrelor

90 interactions 11 explained in plain English
Also sold as: Brilinta
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Ticagrelor Acetaminophen And Codeine Capital® & Codeine Explained Reduced absorption of ticagrelor Details Ticagrelor Abametapir Explained Increased exposure of CYP3A4 substrate Details Ticagrelor Sertraline Explained An increased risk of bleeding Details Ticagrelor Buprenorphine Belbuca Explained Reduced absorption of ticagrelor Details Ticagrelor Relugolix Orgovyx Explained Increased relugolix exposure Details Ticagrelor Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of myopathy, including rhabdomyolysis Details Ticagrelor Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Ticagrelor Apixaban Eliquis Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Ticagrelor Aspirin Acuprin® Increased risk of bleeding Details Ticagrelor Aspirin Rectal Aspirin Increased risk of bleeding Details Ticagrelor Atogepant Qulipta Reduced atogepant exposure Details Ticagrelor Betrixaban Bevyxxa® Increased risk of bleeding Details Ticagrelor Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Ticagrelor Amlodipine Amvaz® Reduced amLODIPine exposure Details Ticagrelor Anagrelide Agrylin Increased bleeding risk Details Ticagrelor Bedaquiline Sirturo Increased bedaquiline exposure Details Ticagrelor Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Ticagrelor Butorphanol Injection Butorphic Reduced absorption of ticagrelor Details Ticagrelor Butorphanol Nasal Spray Stadol® NS Reduced absorption of ticagrelor Details Ticagrelor Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Ticagrelor Clopidogrel Plavix Increased risk of bleeding Details Ticagrelor Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Ticagrelor Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Ticagrelor Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Ticagrelor Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Ticagrelor Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Ticagrelor Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Ticagrelor Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Ticagrelor Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Ticagrelor Digoxin Cardoxin® Increased digoxin exposure Details Ticagrelor Dipyridamole Permole® Increased risk of bleeding Details Ticagrelor Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Ticagrelor Edoxaban Savaysa Increased risk of bleeding Details Ticagrelor Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Ticagrelor Epoprostenol Flolan Increased risk of bleeding Details Ticagrelor Etodolac Lodine An increased risk of bleeding Details Ticagrelor Fenoprofen Fenopron An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.