1,3-dmba - Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Interaction

Herbal: 1,3-dmba

Drug: Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine
Brand names: Conar-A

Medical Content Editor
Last updated Apr 20, 2025

There are multiple interactions reported between these two agents.

Interaction Details

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine is classified as belonging to the following category: Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, 1,3-DMBA might modestly increase the levels of CYP2D6 substrates.
In vitro research shows that 1,3-DMBA weakly inhibits CYP2D6 enzymes.

Interaction Rating

Minor

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10.

Interaction Details

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine is classified as belonging to the following category: Stimulant Drugs

Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.
Animal research shows that 1,3-DMBA has stimulant effects, such as increasing blood pressure and heart rate.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • SWANSON EE, CHEN KK. Comparison of pressor action of alicyclic derivatives of aliphatic amines. J Pharmacol Exp Ther. 1948 Aug;93(4):423-9.

1,3-dmba Overview

1,3-DMBA, also known as 1,3-dimethylbutylamine, is a chemical present in certain supplements advertised for enhancing athletic performance and aiding in weight loss. While some products claim to derive 1,3-DMBA from pouchong tea or Coreopsis tinctoria, the levels found in these supplements far exceed natural quantities, suggesting synthetic production. Consequently, the US FDA has classified supplements containing 1,3-DMBA as adulterated, and the World Anti-Doping Agency prohibits their use. When taken orally, 1,3-DMBA is considered potentially unsafe due to its stimulant and vasoconstrictive properties, similar to those of 1,3-DMAA, a synthetic stimulant associated with severe side effects such as lactic acidosis, myocardial infarction, stroke, and even death. As a result, it is strongly recommended to avoid oral consumption of 1,3-DMBA.
See More Information Regarding 1,3-dmba

1,3-dmba - More Interactions

1,3-dmba interacts with 319 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

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Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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